Emerging landscape of computational modeling in pharmaceutical development
YA Abramov, G Sun, Q Zeng - Journal of Chemical Information …, 2022 - ACS Publications
Computational chemistry applications have become an integral part of the drug discovery
workflow over the past 35 years. However, computational modeling in support of drug …
workflow over the past 35 years. However, computational modeling in support of drug …
Boosting the predictive performance with aqueous solubility dataset curation
Intrinsic solubility is a critical property in pharmaceutical industry that impacts in-vivo
bioavailability of small molecule drugs. However, solubility prediction with Artificial …
bioavailability of small molecule drugs. However, solubility prediction with Artificial …
Development and molecular modeling studies of new thiadiazole piperazine urea derivatives as potential fatty acid amide hydrolase inhibitors
A series of novel piperazine urea derivatives with thiadiazole moieties were designed,
synthesized, and investigated for their inhibition potential against human fatty acid amide …
synthesized, and investigated for their inhibition potential against human fatty acid amide …
Biopharmaceutics tools for rational formulation design
P Zarmpi, M McAllister, J Butler… - … : From Fundamentals to …, 2022 - Wiley Online Library
Product quality is achieved through formulation design and manufacturing process selection
and development with the ultimate guiding principle of ensuring consistent performance for …
and development with the ultimate guiding principle of ensuring consistent performance for …
Preparation of Atorvastatin Calcium-Dipicolinic Acid Multicomponent Solids by Liquid-Assisted Grinding Method to Increase Solubility
Y Wicaksono, SF Tsaniyah, B Wisudyaningsih… - Molekul, 2022 - jos.unsoed.ac.id
Atorvastatin calcium is a cholesterol-lowering drug that is very potent but difficult to dissolve
in water, so its bioavailability is low. In this study, atorvastatin calcium-dipicolinic acid …
in water, so its bioavailability is low. In this study, atorvastatin calcium-dipicolinic acid …
[图书][B] Self-Assembly Dynamics and Energetics at the Solution/Solid Interface: Concentration and Solvent Control
K Gurdumov - 2022 - search.proquest.com
A comprehensive investigation on the formation dynamics and energetics of adlayer
formation at the at the solution/solid interface has been performed using scanning tunneling …
formation at the at the solution/solid interface has been performed using scanning tunneling …
Discontinuous solid solutions of anthracene–phenanthrene: Thermodynamics and crystallization kinetics
Z Zhang, L Zhou, Q Yin - Particuology, 2022 - Elsevier
We explored such issues as the formation mechanism, structure and propriety of the solid
solutions of anthracene (ANT)–phenanthrene (PHE). Solution crystallization and solid-state …
solutions of anthracene (ANT)–phenanthrene (PHE). Solution crystallization and solid-state …