Full spectrum of vitamin D immunomodulation in multiple sclerosis: Mechanisms and therapeutic implications

M Galoppin, S Kari, S Soldati, A Pal… - Brain …, 2022 - academic.oup.com
Vitamin D deficiency has been associated with the risk of multiple sclerosis, disease activity
and progression. Results from in vitro experiments, animal models and analysis of human …

Genetics of multiple sclerosis: lessons from polygenicity

A Goris, M Vandebergh, JL McCauley… - The Lancet …, 2022 - thelancet.com
Large-scale mapping studies have identified 236 independent genetic variants associated
with an increased risk of multiple sclerosis. However, none of these variants are found …

Twin study reveals non-heritable immune perturbations in multiple sclerosis

F Ingelfinger, LA Gerdes, V Kavaka, S Krishnarajah… - Nature, 2022 - nature.com
Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system
underpinned by partially understood genetic risk factors and environmental triggers and …

Molecular biomarkers and their implications for the early diagnosis of selected neurodegenerative diseases

J Doroszkiewicz, M Groblewska, B Mroczko - International Journal of …, 2022 - mdpi.com
The degeneration and dysfunction of neurons are key features of neurodegenerative
diseases (NDs). Currently, one of the main challenges facing researchers and clinicians is …

Genetics and functional genomics of multiple sclerosis

W Kim, NA Patsopoulos - Seminars in immunopathology, 2022 - Springer
Multiple sclerosis (MS) is an inflammatory neurodegenerative disease with genetic
predisposition. Over the last decade, genome-wide association studies with increasing …

Epidemiology of familial multiple sclerosis in Iran: a national registry-based study

Z Salehi, A Almasi-Hashiani, MA Sahraian, F Ashtari… - BMC neurology, 2022 - Springer
Background Admittedly, little is known about the epidemiological signatures of familial
multiple sclerosis (FMS) in different geographical regions of Iran. Objective To determine the …

Gut microbiome in multiple sclerosis-related cognitive impairment

F Ghadiri, Z Ebadi, E Asadollahzadeh… - Multiple Sclerosis and …, 2022 - Elsevier
Cognition is one of the most evaluated neurologic subjects with which the gut microbiome is
supposed to be associated. Cognitive impairment is a prevalent finding in patients with …

Prevalence of multiple sclerosis and its clinical and demographic characteristics in Kurdish populations in western Iran (2020)

N Razazian, S Eskandarieh, S Siabani… - Multiple sclerosis and …, 2022 - Elsevier
Abstract Background Multiple Sclerosis (MS) is a costly burdensome nervous system
disorder leading several disabilities in young and middle-aged people. Knowing MS clinical …

[PDF][PDF] Genetic Identifications for Sample of Multiple Sclerosis Iraqi Patients

FS Hammood, BJ Mohammed - Iraqi Journal of Biotechnology, 2022 - iasj.net
Multiple sclerosis (MS) is an inflammatory condition that affects central nervous system
(CNS) causing neurological dysfunction; T cell immunoglobulin and mucin domain-3 (TIM-3) …

Uncovering genetic risk factors in multiple sclerosis using a family-based approach

M Chen - 2022 - figshare.utas.edu.au
Multiple sclerosis (MS) is one of the most common diseases of the brain and spinal cord,
characterised by demyelination and neurodegeneration. Family and twin studies …