Wound healing in aged skin exhibits systems-level alterations in cellular composition and cell-cell communication

R Vu, S Jin, P Sun, D Haensel, QH Nguyen, M Dragan… - Cell reports, 2022 - cell.com
Delayed and often impaired wound healing in the elderly presents major medical and
socioeconomic challenges. A comprehensive understanding of the cellular/molecular …

[HTML][HTML] Targeting oncogenic transcription factors in skin malignancies: An update on cancer stemness and therapeutic outcomes

M Steinhoff, M Alam, A Ahmad, S Uddin… - Seminars in Cancer …, 2022 - Elsevier
The skin is the largest organ of the human body and prone to various diseases, including
cancer; thus, provides the first line of defense against exogenous biological and non …

FcγRIIB inhibits inflammation in a murine model of psoriasis

I Nakabori, Y Hamaguchi, K Sawada, M Horii… - Journal of …, 2022 - Elsevier
Background Psoriasis is a chronic, inflammatory cutaneous disease. FcγRIIB is a low-affinity
receptor for the IgG Fc fragment that provides a negative feedback pathway to down …

Tumor suppressor p53 deficiency increases tumor immunogenicity through promoting IL33-mediated anti-tumor immune responses

Y Li, DS Gao, L Yi, F Gao, R Sun, KK Lu, J Xu… - bioRxiv, 2022 - biorxiv.org
Recent studies have shown that p53 contributes to poor survival during immune checkpoint
blockade (ICB) therapy. Lung cancer patients with p53 mutations have significantly …