[HTML][HTML] Therapeutic approaches for the treatment of head and neck squamous cell carcinoma–An update on clinical trials

B Goel, AK Tiwari, RK Pandey, AP Singh, S Kumar… - Translational …, 2022 - Elsevier
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common non-skin
cancer with a tobacco consumption and infection with high-risk human papillomavirus (HPV) …

Novel systemic treatment modalities including immunotherapy and molecular targeted therapy for recurrent and metastatic head and neck squamous cell carcinoma

S Ghosh, PA Shah, FM Johnson - International journal of molecular …, 2022 - mdpi.com
Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancers
worldwide. More than half of patients with HNSCC eventually experience disease …

Current status and perspective of tumor immunotherapy for head and neck squamous cell carcinoma

C Yu, Q Li, Y Zhang, ZF Wen, H Dong… - Frontiers in Cell and …, 2022 - frontiersin.org
Head and neck squamous cell carcinoma (HNSCC) have a high incidence and mortality
rate, and investigating the pathogenesis and potential therapeutic strategies of HNSCC is …

Validating a membership disclosure metric for synthetic health data

K El Emam, L Mosquera, X Fang - JAMIA open, 2022 - academic.oup.com
Background One of the increasingly accepted methods to evaluate the privacy of synthetic
data is by measuring the risk of membership disclosure. This is a measure of the F1 …

Radiotherapy, chemotherapy and immunotherapy—current practice and future perspectives for recurrent/metastatic oral cavity squamous cell carcinoma

C Melo-Alvim, ME Neves, JL Santos… - Diagnostics, 2022 - mdpi.com
Oral squamous cell carcinoma is the most common malignant epithelial neoplasm affecting
the oral cavity. While surgical resection is the cornerstone of a multimodal curative …

[HTML][HTML] Efficacy of cetuximab plus PD-1 inhibitor differs by HPV status in head and neck squamous cell carcinoma: a systematic review and meta-analysis

S Zhang, M Zheng, D Nie, L Xu, H Tian… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background The addition of cetuximab significantly increased the antitumor effect of
programmed cell death protein 1 (PD-1) inhibitors in recurrent or metastatic head and neck …

Engineering a single-chain variable fragment of cetuximab for CAR T-cell therapy against head and neck squamous cell carcinomas

C Haist, Z Poschinski, A Bister, MJ Hoffmann… - Oral Oncology, 2022 - Elsevier
The monoclonal antibody cetuximab recognizes domain III of the epithelial growth factor
receptor (EGFR) with high-affinity and is an important element in the treatment of several …

Engaging innate immunity for targeting the epidermal growth factor receptor: Therapeutic options leveraging innate immunity versus adaptive immunity versus …

G Hintzen, HJ Dulat, E Rajkovic - Frontiers in Oncology, 2022 - frontiersin.org
The epidermal growth factor receptor (EGFR) is a key player in the normal tissue physiology
and the pathology of cancer. Therapeutic approaches have now been developed to target …

Finding the right heavy chains for immunostimulatory antibodies

P Boulard, V Gouilleux-Gruart, H Watier - International Journal of …, 2022 - mdpi.com
For twelve years, the oncology field has been revolutionized by antibodies targeting immune
checkpoints. They must be considered as a heterogenous family of immunostimulatory …

Targeting epidermal growth factor receptor in head and neck cancer

A Bhatia - The Cancer Journal, 2022 - journals.lww.com
Head and neck squamous cell carcinomas are rising in incidence worldwide, and despite
the advent of improved surgical and radiation techniques, a substantial proportion of …