Epoxylipids and soluble epoxide hydrolase in heart diseases

JD Imig, L Cervenka, J Neckar - Biochemical pharmacology, 2022 - Elsevier
Cardiovascular and heart diseases are leading causes of morbidity and mortality. Coronary
artery endothelial and vascular dysfunction, inflammation, and mitochondrial dysfunction …

The plasma oxylipin signature provides a deep phenotyping of metabolic syndrome complementary to the clinical criteria

C Dalle, J Tournayre, M Mainka… - International journal of …, 2022 - mdpi.com
Metabolic syndrome (MetS) is a complex condition encompassing a constellation of
cardiometabolic abnormalities. Oxylipins are a superfamily of lipid mediators regulating …

Orally active epoxyeicosatrienoic acid analogs in hypertension and renal injury

JD Imig - Advances in Pharmacology, 2022 - Elsevier
Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites synthesized by
cytochrome P450 epoxygenases. Biological activities for EETs include vasodilation …

Oxylipin profiling identifies a mechanistic signature of metabolic syndrome: results from two independent cohorts

C Dalle, J Tournayre, M Mainka, A Basiak-Rasała… - medRxiv, 2022 - medrxiv.org
Abstract Background Metabolic syndrome (MetS) is a complex condition encompassing a
constellation of cardiometabolic abnormalities. Integratively phenotyping the molecular …