Simple Summary KRAS and genes in the RAS-MAPK pathway are among the most
frequently deregulated genes in solid tumors and in this context a large amount of KRAS …

Background We assessed the mechanism by which multiple myeloma (MM) shapes the
bone marrow (BM) microenvironment and affects MΦ polarization. Methods In vivo xenograft …

Multiple myeloma (MM) remains an incurable, genetically heterogeneous disease
characterized by the uncontrolled proliferation of transformed plasma cells nurtured within a …

Oncogenic activated RAS mutations have been detected in 50% of de novo and 70% of
relapsed multiple myeloma (MM) patients. Translocation t (11; 14) involving IgH/CCDN1 and …

Our view on the role and composition of the bone marrow (BM) has dramatically changed
over time from a simple nutrient for the bone to a highly complex multicellular tissue that …

Multiple myeloma (MM), a malignant plasma cell infiltration of the bone marrow, is generally
considered incurable: resistance to multiple therapeutic drugs inevitably arises from tumor …

Simple Summary This study was designed to investigate the potential for targeting the NF-κB-
inducing kinase, NIK, in two common B-cell malignancies, chronic lymphocytic leukemia …

Ruxolitinib with lenalidomide and dexamethasone shows anti‐myeloma effects in vitro and
in vivo. MUC1 leads to lenalidomide resistance in multiple myeloma (MM) cells, and …

The microenvironment of cancer cells is receiving increasing attention as an important factor
influencing the progression and prognosis of tumor diseases. In Multiple Myeloma (MM), a …

Multiple myeloma (MM) is a monoclonal gammopathy characterized by biological
heterogeneity and unregulated proliferation of plasma cells (PCs) in bone marrow (BM). MM …