Cardiac glycosides cause cytotoxicity in human macrophages and ameliorate white adipose tissue homeostasis

A Olona, C Hateley, A Guerrero, JH Ko… - British Journal of …, 2022 - Wiley Online Library
Background and Purpose Cardiac glycosides inhibit Na+/K+‐ATPase and are used to treat
heart failure and arrhythmias. They can induce inflammasome activation and pyroptosis in …

Expression of the Adipocyte Progenitor Markers MSCA1 and CD36 is Associated With Adipose Tissue Function in Children

M Hanschkow, N Boulet, E Kempf… - The Journal of …, 2022 - academic.oup.com
Context MSCA1 (mesenchymal stem cell antigen 1) and CD36 (cluster of differentiation 36)
have been described as novel adipocyte progenitor markers in adults with a potential …

Exploring the multi-tissue crosstalk relevant to insulin resistance through network-based analysis

L Yang, L Yang, X Wang, H Xing, H Zhao… - Frontiers in …, 2022 - frontiersin.org
Insulin resistance (IR) is a precursor event that occurs in multiple organs and underpins
many metabolic disorders. However, due to the lack of effective means to systematically …

Sphingolipids in Adipose: Kin or Foe?

Y Valentine, LA Cowart - Sphingolipid Metabolism and Metabolic Disease, 2022 - Springer
Obesity research has shifted in recent years to address not only the total amount of adipose
tissue present in an individual but also to include adipose tissue functions such as …

PCSK9 dysregulates cholesterol homeostasis and triglyceride metabolism in olanzapine-induced hepatic steatosis via both receptor-dependent and-independent …

W Zhu, P Huang, R Li, J Ran, W Dai, Y Tang, P Lian… - 2022 - researchsquare.com
Background Long-term olanzapine treatment reportedly induces nonalcoholic fatty liver
disease (NAFLD); however, the underlying mechanism remains unclear. Proprotein …

The Roles of G-protein Coupled Receptor Kinase 5 in Adipocyte Differentiation and Lipid Metabolism Using a 3T3-L1 Cell Model

BT McDonald - 2022 - search.proquest.com
Obesity is a growing health concern and identifying genetic and environmental risk factors is
crucial for understanding the disease and possible therapies. Using the heterogeneous …

[PDF][PDF] Análise molecular e funcional da modulação da fosforilação do PPARγ em camundongos alimentados com dieta hiperlipídica

MF Terra - 2022 - repositorio.unicamp.br
Obesidade é uma patologia caracterizada pelo acúmulo de tecido adiposo em proporções
que afetam a saúde dos indivíduos e tem atingido proporções epidêmicas no mundo. Esses …

A pharmacological study of pioglitazone in the regulation of adipocyte differentiation.

C Qin, Q Wan, L Xi, M Wei, Q Du - Journal of Chinese …, 2022 - search.ebscohost.com
As a pathological result of the abnormal differentiation of adipocytes, the occurrence of
obesity will not only lead to weight gain, abnormal energy metabolism, but also the …