[HTML][HTML] Oxidative stress in human pathology and aging: molecular mechanisms and perspectives

YA Hajam, R Rani, SY Ganie, TA Sheikh, D Javaid… - Cells, 2022 - mdpi.com
Reactive oxygen and nitrogen species (RONS) are generated through various endogenous
and exogenous processes; however, they are neutralized by enzymatic and non-enzymatic …

[HTML][HTML] Signaling pathways of chronic kidney diseases, implications for therapeutics

Q Yuan, B Tang, C Zhang - Signal transduction and targeted therapy, 2022 - nature.com
Chronic kidney disease (CKD) is a chronic renal dysfunction syndrome that is characterized
by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) …

[HTML][HTML] Therapeutic effects of green tea polyphenol (‒)-Epigallocatechin-3-Gallate (EGCG) in relation to molecular pathways controlling inflammation, oxidative stress …

D Mokra, M Joskova, J Mokry - International journal of molecular sciences, 2022 - mdpi.com
(‒)-Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in green tea.
Thanks to multiple interactions with cell surface receptors, intracellular signaling pathways …

[HTML][HTML] The role of oxidative stress in skeletal muscle myogenesis and muscle disease

D Lian, MM Chen, H Wu, S Deng, X Hu - Antioxidants, 2022 - mdpi.com
The contractile activity, high oxygen consumption and metabolic rate of skeletal muscle
cause it to continuously produce moderate levels of oxidant species, such as reactive …

[HTML][HTML] Vaccination in patients with kidney failure: lessons from COVID-19

N Babel, C Hugo, TH Westhoff - Nature Reviews Nephrology, 2022 - nature.com
Infection is the second leading cause of death in patients with chronic kidney disease (CKD).
Adequate humoral (antibody) and cellular (T cell-driven) immunity are required to minimize …

[HTML][HTML] The functions and roles of sestrins in regulating human diseases

Y Chen, T Huang, Z Yu, Q Yu, Y Wang, J Hu… - Cellular & Molecular …, 2022 - Springer
Sestrins (Sesns), highly conserved stress-inducible metabolic proteins, are known to protect
organisms against various noxious stimuli including DNA damage, oxidative stress …

[HTML][HTML] GlyNAC (glycine and N-acetylcysteine) supplementation in mice increases length of life by correcting glutathione deficiency, oxidative stress, mitochondrial …

P Kumar, OW Osahon, RV Sekhar - Nutrients, 2022 - mdpi.com
Determinants of length of life are not well understood, and therefore increasing lifespan is a
challenge. Cardinal theories of aging suggest that oxidative stress (OxS) and mitochondrial …

Effects of air pollution on human health–mechanistic evidence suggested by in vitro and in vivo modelling

H Chen, BG Oliver, A Pant, A Olivera, P Poronnik… - Environmental …, 2022 - Elsevier
Airborne particulate matter (PM) comprises both solid and liquid particles, including carbon,
sulphates, nitrate, and toxic heavy metals, which can induce oxidative stress and …

[HTML][HTML] Carotenoids in human skin in vivo: Antioxidant and photo-protectant role against external and internal stressors

ME Darvin, J Lademann, J von Hagen, SB Lohan… - Antioxidants, 2022 - mdpi.com
The antioxidant system of the human body plays a crucial role in maintaining redox
homeostasis and has an important protective function. Carotenoids have pronounced …

Recent advances in nanogold as a promising nanocarrier for curcumin delivery

A Mahmoudi, P Kesharwani, M Majeed, Y Teng… - Colloids and Surfaces B …, 2022 - Elsevier
Curcumin is a natural polyphenolic compound that has promising therapeutic benefits.
However, curcumin suffers from low aqueous solubility and poor bioavailability following …