[HTML][HTML] Recent advances and limitations of mTOR inhibitors in the treatment of cancer
Abstract The PI3K-Akt-mechanistic (formerly mammalian) target of the rapamycin (mTOR)
signaling pathway is important in a variety of biological activities, including cellular …
signaling pathway is important in a variety of biological activities, including cellular …
[HTML][HTML] Precision drugging of the MAPK pathway in head and neck cancer
HL Ngan, CH Law, YCY Choi, JYS Chan… - NPJ genomic …, 2022 - nature.com
The mitogen-activating protein kinase (MAPK) pathway is central for cell proliferation,
differentiation, and senescence. In human, germline defects of the pathway contribute to …
differentiation, and senescence. In human, germline defects of the pathway contribute to …
Combination of BMI1 and MAPK/ERK inhibitors is effective in medulloblastoma
S Badodi, N Pomella, YM Lim, S Brandner… - Neuro …, 2022 - academic.oup.com
Background Epigenetic changes play a key role in the pathogenesis of medulloblastoma
(MB), the most common malignant pediatric brain tumor. Methods We explore the …
(MB), the most common malignant pediatric brain tumor. Methods We explore the …
[HTML][HTML] Characterization of tumor immune microenvironment and cancer therapy for head and neck squamous cell carcinoma through identification of a genomic …
L Jing, Y Du, D Fu - Frontiers in Genetics, 2022 - frontiersin.org
Head and neck squamous cell carcinoma (HNSCC) represents one of the most prevalent
and malignant tumors of epithelial origins with unfavorable outcomes. Increasing evidence …
and malignant tumors of epithelial origins with unfavorable outcomes. Increasing evidence …
Advances in autophagy as a target in the treatment of tumours
Y Li, S Gao, X Du, J Ji, Y Xi, G Zhai - Journal of Drug Targeting, 2022 - Taylor & Francis
Autophagy is a multi-step lysosomal degradation process, which regulates energy and
material metabolism and has been used to maintain homeostasis. Autophagy has been …
material metabolism and has been used to maintain homeostasis. Autophagy has been …
Precision drugging of the MAPK pathway in head and neck cancer
N Hoi-Lam, L Chun-Ho, CYC Yan… - NPJ Genomic …, 2022 - search.proquest.com
The mitogen-activating protein kinase (MAPK) pathway is central for cell proliferation,
differentiation, and senescence. In human, germline defects of the pathway contribute to …
differentiation, and senescence. In human, germline defects of the pathway contribute to …
Novel mTOR inhibitors: Promising therapeutic interventions in oral cancer therapy
D Ezhilarasan, KS Harini - Oral oncology, 2022 - pubmed.ncbi.nlm.nih.gov
Novel mTOR inhibitors: Promising therapeutic interventions in oral cancer therapy Novel mTOR
inhibitors: Promising therapeutic interventions in oral cancer therapy Oral Oncol. 2022 …
inhibitors: Promising therapeutic interventions in oral cancer therapy Oral Oncol. 2022 …