The tumor suppressor p53 when undergoes amyloid formation confers several gain-of-
function (GOF) activities that affect molecular pathways crucial for tumorigenesis and …

Transcription factor p53 (also known as TP53) has been shown to aggregate into
cytoplasmic and nuclear inclusions, compromising its native tumor suppressive functions …

Recent studies suggested that aggregates of mutant p53 proteins may propagate and impair
normal p53 functioning in recipient cells. Our previous study showed that cancer cell-derived …

Background Neuroblastoma (NB) is the most frequent solid tumor in pediatrics, which
accounts for roughly 15% of cancer-related mortality in children. NB exhibited genetic …

Neuroblastomas are one of the most common types of solid tumors in infants and children
and are responsible for approximately 15% of childhood cancer deaths. Neuroblastomas …

An accurate assessment of TP53's functional status is critical for cancer genomic medicine.
However, there is a significant challenge in identifying tumors with non-mutational p53 …

Background HeberFERON is a co-formulation of α2b and γ interferons, based on their
synergism, that have shown its clinical superiority over individual interferons in basal cell …

Although an aging population has led to a growing socioeconomic burden of
neurodegenerative diseases such as Alzheimer's disease (AD), inadequate techniques for …