Chronic kidney disease (CKD) is a progressive disease that affects millions of adults every
year. Major risk factors include diabetes, hypertension, and obesity, which affect millions of …

As part of the glomerular filtration membrane, podocyte is terminally differentiated,
structurally unique, and highly specialized in maintaining kidney function. Proteinuria …

Excessive accumulation of advanced glycation end products (AGEs) contributes to
autophagy interruption on podocytes and insufficient autophagy on podocytes is …

Diabetic nephropathy (DN), a metabolic disease, is characterized by severe systemic
metabolic disorders. A unique dietary pattern, such as intermittent fasting (IF) has shown …

Autophagy is a process that degrades endogenous cellular protein aggregates and
damaged organelles via the lysosomal pathway to maintain cellular homeostasis and …

Background. Type 2 diabetes mellitus (T2DM), especially hyperglycemia, is associated with
increased glucose cell toxicity and oxidative stress that can lead to irreversible damage in …

Zinc pyrithione (ZPT) is a frequently used organometallic biocide, carrying potentially
adverse consequences to multiple species in the environment. Previously we have …

High plasma levels of lipids and/or lipoproteins are risk factors for atherosclerosis,
nonalcoholic fatty liver disease (NAFLD), obesity, and diabetes. These four conditions have …

Integrin α3β1 is a cell adhesion receptor widely expressed in epithelial cells. Pathogenic
variants in the gene encoding the integrin α3 subunit ITGA3 lead to a syndrome including …

肾脏纤维化是所有慢性肾病发展为终末期肾病的最终共同途径. 自噬是一种高度保守的溶酶体
降解途径, 在维持所有主要类型的肾细胞, 包括肾小管细胞, 足细胞, 系膜细胞和肾小球内皮细胞 …