Mechanism and therapeutic targets of c-jun-N-terminal kinases activation in nonalcoholic fatty liver disease
RWM Min, FWM Aung, B Liu, A Arya, S Win - Biomedicines, 2022 - mdpi.com
Non-alcoholic fatty liver (NAFL) is the most common chronic liver disease. Activation of
mitogen-activated kinases (MAPK) cascade, which leads to c-Jun N-terminal kinase (JNK) …
mitogen-activated kinases (MAPK) cascade, which leads to c-Jun N-terminal kinase (JNK) …
[PDF][PDF] Effect of ellagic acid on damage caused by hepatic ischemia reperfusion in rats.
OBJECTIVE: Ischemia (I) causes lack of oxygen delivery to the tissues, leading to hypoxia
and cellular damage. Reperfusion (R) is the re-blooded of the tissue; however, it may cause …
and cellular damage. Reperfusion (R) is the re-blooded of the tissue; however, it may cause …
The E3 ubiquitin ligase TRIM31 plays a critical role in hypertensive nephropathy by promoting proteasomal degradation of MAP3K7 in the TGF-β1 signaling pathway
Renal fibrosis and inflammation are critical for the initiation and progression of hypertensive
renal disease (HRD). However, the signaling mechanisms underlying their induction are …
renal disease (HRD). However, the signaling mechanisms underlying their induction are …
Single cell transcriptional diversity and intercellular crosstalk of human liver cancer
Y Meng, Y Sang, J Liao, Q Zhao, S Qu, R Li… - Cell Death & …, 2022 - nature.com
Liver cancer arises from the evolutionary selection of the dynamic tumor microenvironment
(TME), in which the tumor cell generally becomes more heterogeneous; however, the …
(TME), in which the tumor cell generally becomes more heterogeneous; however, the …
Transforming growth factor-β activated kinase 1 (Tak1) is activated in hepatocellular carcinoma, mediates tumor progression, and predicts unfavorable outcome
DA Ridder, LL Urbansky, HR Witzel, M Schindeldecker… - Cancers, 2022 - mdpi.com
Simple Summary Chronic inflammation is known to drive cancer initiation and progression in
the liver and other organs. In different genetic mouse models, the role of the pro …
the liver and other organs. In different genetic mouse models, the role of the pro …
Hyaluronan synthase 2, a target of miR-200c, promotes carbon tetrachloride-induced acute and chronic liver inflammation via regulation of CCL3 and CCL4
SM Kim, GY Song, A Shim, JH Lee, CB Eom… - … & molecular medicine, 2022 - nature.com
Liver fibrosis occurs during wound healing after repeated liver injury and is characterized by
extensive extracellular matrix deposition. We previously identified hyaluronan synthase 2 …
extensive extracellular matrix deposition. We previously identified hyaluronan synthase 2 …
Hepatocyte-specific Smad4 deficiency alleviates liver fibrosis via the p38/p65 pathway
M Wei, X Yan, X Xin, H Chen, L Hou… - International Journal of …, 2022 - mdpi.com
Liver fibrosis is a wound-healing response caused by the abnormal accumulation of
extracellular matrix, which is produced by activated hepatic stellate cells (HSCs). Most …
extracellular matrix, which is produced by activated hepatic stellate cells (HSCs). Most …
Cancer chemopreventive potential of cooked glutinous purple rice on the early stages of hepatocarcinogenesis in rats
H Guo, C Punvittayagul, A Vachiraarunwong… - Frontiers in …, 2022 - frontiersin.org
Cancer prevention using dietary phytochemicals holds great potential, particularly in the
alternative treatment of liver cancer. Our previous study found that the methanol extract of …
alternative treatment of liver cancer. Our previous study found that the methanol extract of …
[PDF][PDF] Evaluation of the hepatoprotective and antioxidant effects of Tegillarca granosa flesh body extract against potassium bromide toxicity via targeting the …
The hepatotoxic effect of potassium bromide (KBr) on rat liver tissues were determined, as
well as the potential protective effect of Tegillaraca granosa (T. granosa) flesh body extract …
well as the potential protective effect of Tegillaraca granosa (T. granosa) flesh body extract …
[PDF][PDF] Effects of Carvedilol on liver ischemia-reperfusion injury in rats
MT Kafadar, MA Gök - Turkish Journal of Trauma & …, 2022 - jag.journalagent.com
ABSTRACT BACKGROUND: The aim of this study was to analyze the potential protective
effect of Carvedilol against liver ischemia-reperfusion (I/R) injury in rats. METHODS: A total …
effect of Carvedilol against liver ischemia-reperfusion (I/R) injury in rats. METHODS: A total …