Protein–RNA interaction prediction with deep learning: structure matters
Protein–RNA interactions are of vital importance to a variety of cellular activities. Both
experimental and computational techniques have been developed to study the interactions …
experimental and computational techniques have been developed to study the interactions …
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
Variants of UNC13A, a critical gene for synapse function, increase the risk of amyotrophic
lateral sclerosis and frontotemporal dementia,–, two related neurodegenerative diseases …
lateral sclerosis and frontotemporal dementia,–, two related neurodegenerative diseases …
RNA-binding proteins in the regulation of adipogenesis and adipose function
P Zhang, W Wu, C Ma, C Du, Y Huang, H Xu, C Li… - Cells, 2022 - mdpi.com
The obesity epidemic represents a critical public health issue worldwide, as it is a vital risk
factor for many diseases, including type 2 diabetes (T2D) and cardiovascular disease …
factor for many diseases, including type 2 diabetes (T2D) and cardiovascular disease …
Sorting and packaging of RNA into extracellular vesicles shape intracellular transcript levels
Abstract Background Extracellular vesicles (EVs) are released by nearly every cell type and
have attracted much attention for their ability to transfer protein and diverse RNA species …
have attracted much attention for their ability to transfer protein and diverse RNA species …
iLoc-miRNA: extracellular/intracellular miRNA prediction using deep BiLSTM with attention mechanism
The location of microRNAs (miRNAs) in cells determines their function in regulation activity.
Studies have shown that miRNAs are stable in the extracellular environment that mediates …
Studies have shown that miRNAs are stable in the extracellular environment that mediates …
LINE1 are spliced in non-canonical transcript variants to regulate T cell quiescence and exhaustion
F Marasca, S Sinha, R Vadalà, B Polimeni, V Ranzani… - Nature …, 2022 - nature.com
How gene expression is controlled to preserve human T cell quiescence is poorly
understood. Here we show that non-canonical splicing variants containing long interspersed …
understood. Here we show that non-canonical splicing variants containing long interspersed …
Profiling lariat intermediates reveals genetic determinants of early and late co-transcriptional splicing
Long introns with short exons in vertebrate genes are thought to require spliceosome
assembly across exons (exon definition), rather than introns, thereby requiring transcription …
assembly across exons (exon definition), rather than introns, thereby requiring transcription …
Regulation of alternative polyadenylation by the C2H2-zinc-finger protein Sp1
Alternative polyadenylation (APA) enhances gene regulatory potential by increasing the
diversity of mRNA transcripts. 3′ UTR shortening through APA correlates with enhanced …
diversity of mRNA transcripts. 3′ UTR shortening through APA correlates with enhanced …
Systematic exploration of dynamic splicing networks reveals conserved multistage regulators of neurogenesis
Alternative splicing (AS) is a critical regulatory layer; yet, factors controlling functionally
coordinated splicing programs during developmental transitions are poorly understood …
coordinated splicing programs during developmental transitions are poorly understood …
Diverse cell-specific patterns of alternative polyadenylation in Drosophila
Most genes in higher eukaryotes express isoforms with distinct 3'untranslated regions
(3'UTRs), generated by alternative polyadenylation (APA). Since 3'UTRs are predominant …
(3'UTRs), generated by alternative polyadenylation (APA). Since 3'UTRs are predominant …