Type 2 inflammation in eosinophilic esophagitis: from pathophysiology to therapeutic targets

F Racca, G Pellegatta, G Cataldo, E Vespa… - Frontiers in …, 2022 - frontiersin.org
Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease of the esophagus
characterized clinically by symptoms related to esophageal dysfunction and histologically by …

Eosinophilic esophagitis: Immune mechanisms and therapeutic targets

D Khokhar, S Marella, G Idelman… - Clinical & …, 2022 - Wiley Online Library
Eosinophilic esophagitis (EoE) is an emerging chronic inflammatory disease of the
oesophagus and is clinically characterized by upper gastrointestinal (GI) symptoms …

World Health Organization‐defined eosinophilic disorders: 2022 update on diagnosis, risk stratification, and management

W Shomali, J Gotlib - American journal of hematology, 2022 - Wiley Online Library
Abstract Disease Overview The eosinophilias encompass a broad range of nonhematologic
(secondary or reactive) and hematologic (primary or clonal) disorders with potential for end …

Benralizumab completely depletes gastrointestinal tissue eosinophils and improves symptoms in eosinophilic gastrointestinal disease

FL Kuang, MS De Melo, M Makiya, S Kumar… - The Journal of Allergy …, 2022 - Elsevier
Background Previous studies of targeted eosinophil biologics in eosinophilic esophagitis
have yielded mixed results. Possible explanations include incomplete eosinophil depletion …

Disease burden and unmet need in eosinophilic esophagitis

AJ Bredenoord, K Patel, AM Schoepfer… - Official journal of the …, 2022 - journals.lww.com
Eosinophilic esophagitis (EoE) is a chronic, progressive, type 2 inflammatory disease of
increasing prevalence, characterized by symptoms of dysphagia and reduced quality of life …

[HTML][HTML] Current and emerging biologic therapies targeting eosinophilic disorders

MM Pitlick, JT Li, T Pongdee - World Allergy Organization Journal, 2022 - Elsevier
Eosinophilic disorders include a wide array of conditions in which eosinophils play a primary
pathophysiologic role. While historically treated with corticosteroids and …

Characterization of eosinophilic esophagitis variants by clinical, histological, and molecular analyses: A cross‐sectional multi‐center study

T Greuter, A Straumann, Y Fernandez‐Marrero… - Allergy, 2022 - Wiley Online Library
Objective Physicians are increasingly confronted with patients presenting with symptoms of
esophageal dysfunction resembling eosinophilic esophagitis (EoE), but absence of …

Scientific journey to the first FDA-approved drug for eosinophilic esophagitis

ME Rothenberg - Journal of Allergy and Clinical Immunology, 2022 - Elsevier
When eosinophilia was first associated with esophagitis, it was thought to reflect
gastroesophageal reflux disease, especially given the efficacy of reflux medications to abate …

[HTML][HTML] Eosinophilic esophagitis: New molecules, better life?

AY Lam, C Ma, JK Lee, AJ Bredenoord - Current opinion in pharmacology, 2022 - Elsevier
Eosinophilic esophagitis (EoE) is an antigen-mediated chronic T helper type 2 (Th2)-
associated inflammatory disorder that has emerged in the last three decades as an …

[HTML][HTML] Recent advances in understanding the role of eosinophils

GM Constantine, AD Klion - Faculty Reviews, 2022 - ncbi.nlm.nih.gov
Our understanding of eosinophil biology, development, and regulation has dramatically
increased in the past decade, leading to new paradigms for the role of eosinophils in human …