Type 2 inflammation in eosinophilic esophagitis: from pathophysiology to therapeutic targets
F Racca, G Pellegatta, G Cataldo, E Vespa… - Frontiers in …, 2022 - frontiersin.org
Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease of the esophagus
characterized clinically by symptoms related to esophageal dysfunction and histologically by …
characterized clinically by symptoms related to esophageal dysfunction and histologically by …
Eosinophilic esophagitis: Immune mechanisms and therapeutic targets
D Khokhar, S Marella, G Idelman… - Clinical & …, 2022 - Wiley Online Library
Eosinophilic esophagitis (EoE) is an emerging chronic inflammatory disease of the
oesophagus and is clinically characterized by upper gastrointestinal (GI) symptoms …
oesophagus and is clinically characterized by upper gastrointestinal (GI) symptoms …
World Health Organization‐defined eosinophilic disorders: 2022 update on diagnosis, risk stratification, and management
W Shomali, J Gotlib - American journal of hematology, 2022 - Wiley Online Library
Abstract Disease Overview The eosinophilias encompass a broad range of nonhematologic
(secondary or reactive) and hematologic (primary or clonal) disorders with potential for end …
(secondary or reactive) and hematologic (primary or clonal) disorders with potential for end …
Benralizumab completely depletes gastrointestinal tissue eosinophils and improves symptoms in eosinophilic gastrointestinal disease
FL Kuang, MS De Melo, M Makiya, S Kumar… - The Journal of Allergy …, 2022 - Elsevier
Background Previous studies of targeted eosinophil biologics in eosinophilic esophagitis
have yielded mixed results. Possible explanations include incomplete eosinophil depletion …
have yielded mixed results. Possible explanations include incomplete eosinophil depletion …
Disease burden and unmet need in eosinophilic esophagitis
AJ Bredenoord, K Patel, AM Schoepfer… - Official journal of the …, 2022 - journals.lww.com
Eosinophilic esophagitis (EoE) is a chronic, progressive, type 2 inflammatory disease of
increasing prevalence, characterized by symptoms of dysphagia and reduced quality of life …
increasing prevalence, characterized by symptoms of dysphagia and reduced quality of life …
[HTML][HTML] Current and emerging biologic therapies targeting eosinophilic disorders
MM Pitlick, JT Li, T Pongdee - World Allergy Organization Journal, 2022 - Elsevier
Eosinophilic disorders include a wide array of conditions in which eosinophils play a primary
pathophysiologic role. While historically treated with corticosteroids and …
pathophysiologic role. While historically treated with corticosteroids and …
Characterization of eosinophilic esophagitis variants by clinical, histological, and molecular analyses: A cross‐sectional multi‐center study
T Greuter, A Straumann, Y Fernandez‐Marrero… - Allergy, 2022 - Wiley Online Library
Objective Physicians are increasingly confronted with patients presenting with symptoms of
esophageal dysfunction resembling eosinophilic esophagitis (EoE), but absence of …
esophageal dysfunction resembling eosinophilic esophagitis (EoE), but absence of …
Scientific journey to the first FDA-approved drug for eosinophilic esophagitis
ME Rothenberg - Journal of Allergy and Clinical Immunology, 2022 - Elsevier
When eosinophilia was first associated with esophagitis, it was thought to reflect
gastroesophageal reflux disease, especially given the efficacy of reflux medications to abate …
gastroesophageal reflux disease, especially given the efficacy of reflux medications to abate …
[HTML][HTML] Eosinophilic esophagitis: New molecules, better life?
AY Lam, C Ma, JK Lee, AJ Bredenoord - Current opinion in pharmacology, 2022 - Elsevier
Eosinophilic esophagitis (EoE) is an antigen-mediated chronic T helper type 2 (Th2)-
associated inflammatory disorder that has emerged in the last three decades as an …
associated inflammatory disorder that has emerged in the last three decades as an …
[HTML][HTML] Recent advances in understanding the role of eosinophils
GM Constantine, AD Klion - Faculty Reviews, 2022 - ncbi.nlm.nih.gov
Our understanding of eosinophil biology, development, and regulation has dramatically
increased in the past decade, leading to new paradigms for the role of eosinophils in human …
increased in the past decade, leading to new paradigms for the role of eosinophils in human …