The study of physical and mechanical features of cancer cells, or cancer cell
mechanobiology, is a new frontier in cancer research. Such studies may enhance our …

Inherited cardiomyopathies are a major cause of mortality and morbidity worldwide and can
be caused by mutations in a wide range of proteins located in different cellular …

Emerin is an integral nuclear envelope protein that participates in the maintenance of
nuclear shape. When mutated or absent, emerin causes X-linked Emery-Dreifuss muscular …

Nucleophagy is an organelle-selective subtype of autophagy that targets nuclear material for
degradation. The macroautophagic delivery of micronuclei to the vacuole, together with the …

Mechanical forces play pivotal roles in directing cell functions and fate. To elicit gene
expression, either intrinsic or extrinsic mechanical information are transmitted into the …

The nuclear envelope (NE) is a specialized extension of the endoplasmic reticulum critical
for the proper protection and organization of the genome. This interphase-only structure is …

Organ primordia shape is important for pattern formation and organ function. Morphogenesis
generates forces through cellular rearrangements, proliferation, and shape change. These …

As aging proceeds, the occurrence of cardiovascular diseases increases independent of
other risk factors. At atherosclerotic sites, the rise in the senescent cell population was also …

Nuclear envelope proteins play an important role in regulating nuclear size and structure in
cancer. Altered expression of nuclear lamins are found in many cancers and it's expression …