Developments on the Smart Hydrogel-Based Drug Delivery System for Oral Tumor Therapy

Y Zhao, B Ran, X Xie, W Gu, X Ye, J Liao - Gels, 2022 - mdpi.com
At present, an oral tumor is usually treated by surgery combined with preoperative or
postoperative radiotherapies and chemotherapies. However, traditional chemotherapies …

Head and neck squamous cell carcinoma in elderly patients: role of radiotherapy and chemotherapy

M Fasano, I D'Onofrio, MP Belfiore, A Angrisani… - Cancers, 2022 - mdpi.com
Simple Summary The focus of this review deals with the management of elderly patients with
head and neck squamous cell carcinoma, discussing the role of clinical management …

Phase II study of dichloroacetate, an inhibitor of pyruvate dehydrogenase, in combination with chemoradiotherapy for unresected, locally advanced head and neck …

SF Powell, M Mazurczak, EG Dib, JS Bleeker… - Investigational new …, 2022 - Springer
Chemoradiotherapy (CRT) for locally-advanced head and neck squamous cell carcinoma
(LA-HSNCC) yields 5-year survival rates near 50% despite causing significant toxicity …

Novel strategies for the bioavailability augmentation and efficacy improvement of natural products in oral cancer

A Sachdeva, D Dhawan, GK Jain, MB Yerer… - Cancers, 2022 - mdpi.com
Simple Summary Oral cancer is a major cause of death worldwide. The major challenges
associated with the conventionally used treatment modalities include the recurrence of the …

Prognostic value of tumor-infiltrating immune cells and immune checkpoints in elderly head-and-neck squamous cell carcinoma patients undergoing definitive (chemo …

A Rühle, J Todorovic, SSK Spohn, E Gkika, C Becker… - Radiation …, 2022 - Springer
Background and purpose Tumor-infiltrating lymphocytes (TILs) are associated with
locoregional control (LRC) in head-and-neck squamous cell carcinoma (HNSCC) patients …

[HTML][HTML] Evolution of a paradigm switch in diagnosis and treatment of HPV-driven head and neck cancer—striking the balance between toxicity and cure

B Tawk, J Debus, A Abdollahi - Frontiers in Pharmacology, 2022 - frontiersin.org
More than a decade after the discovery of p16 immunohistochemistry (IHC) as a surrogate
for human papilloma virus (HPV)-driven head and neck squamous cell carcinoma (HNSCC) …

Outcomes for recurrent oral cavity squamous cell carcinoma

KJ Contrera, ME Zafereo, D Yaniv, DB Roberts… - Oral Oncology, 2022 - Elsevier
Objectives We sought to determine overall survival (OS), prognostic factors, cost, and
functional outcomes after surgery for locally recurrent oral cavity squamous cell carcinoma …

[HTML][HTML] Patterns-of-care analysis for radiotherapy of elderly head-and-neck cancer patients: a trinational survey in Germany, Austria and Switzerland

E Haehl, A Rühle, S Spohn, T Sprave, E Gkika… - Frontiers in …, 2022 - frontiersin.org
Objectives The number of elderly head-and-neck squamous cell carcinoma (HNSCC)
patients is increasing, and clinical trials defining the standard of care either excluded or …

Randomized phase 3, double-blind, placebo-controlled study of prophylactic gabapentin for the reduction of oral mucositis pain during the treatment of oropharyngeal …

A Cook, A Modh, H Ali, J Sheqwara, S Chang… - International Journal of …, 2022 - Elsevier
Purpose The purpose of this paper is to determine whether prophylactic gabapentin usage
in patients undergoing definitive concurrent chemotherapy and radiation therapy (chemoRT) …

Current evidence of a deintensification strategy for patients with hpv-related oropharyngeal cancer

SY Sung, YS Kim, SH Kim, SJ Lee, SW Lee, YK Kwak - Cancers, 2022 - mdpi.com
Simple Summary Human papillomavirus (HPV)-related oropharyngeal cancer represents a
distinct disease entity, showing favorable treatment responses and survival outcomes. While …