This article reviews the discovery of PCSK9, its structure–function characteristics, and its
presently known and proposed novel biological functions. The major critical function of …

The proprotein convertase subtilisin/kexin-type 9 (PCSK9) binds to low-density lipoprotein
receptors (LDLR), thereby trafficking them to lysosomes upon endocytosis and enhancing …

Abstract Purpose of Review Since the discovery of PCSK9 in 2003, this proprotein
convertase was shown to target specific receptors for degradation in endosomes/lysosomes …

Based on the structural and signaling roles of cholesterol, which are necessary for immune
cell activity, high concentrations of cholesterol and its metabolites not only trigger malignant …

Low-density lipoprotein (LDL) is the main carrier of cholesterol and cholesteryl ester in
circulation. High plasma levels of LDL cholesterol (LDL-C) are a major risk factor of …

Low-density lipoprotein cholesterol (LDL-C) plays a central role in the pathology of
atherosclerotic cardiovascular disease. For decades, the gold standard for LDL-C lowering …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein and a critical
regulator of low-density lipoprotein-cholesterol (LDL-C) through inducing degradation of the …

Proprotein convertase substilisin/kexin 9 (PCSK9) inhibitors (PCSK9i) revolutionised the
lipid-lowering therapy. However, a risk of type 2 diabetes mellitus (T2DM) is evoked under …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is involved in the degradation of the
low-density lipoprotein receptor. PCSK9 also targets proteins involved in lipid metabolism …

Protein convertases (PCs) play a significant role in post-translational procedures by
transforming inactive precursor proteins into their active forms. The role of PCs is crucial for …