Intra-pancreatic fat deposition: bringing hidden fat to the fore

MS Petrov, R Taylor - Nature Reviews Gastroenterology & Hepatology, 2022 - nature.com
Abstract Development of advanced modalities for detection of fat within the pancreas has
transformed understanding of the role of intra-pancreatic fat deposition (IPFD) in health and …

Metabolic implications of pancreatic fat accumulation

R Wagner, SS Eckstein, H Yamazaki, F Gerst… - Nature Reviews …, 2022 - nature.com
Fat accumulation outside subcutaneous adipose tissue often has unfavourable effects on
systemic metabolism. In addition to non-alcoholic fatty liver disease, which has received …

[HTML][HTML] Intestinal barrier function and immune homeostasis are missing links in obesity and type 2 diabetes development

S Riedel, C Pheiffer, R Johnson, J Louw… - Frontiers in …, 2022 - frontiersin.org
Noncommunicable diseases, such as type 2 diabetes (T2D), place a burden on healthcare
systems worldwide. The rising prevalence of obesity, a major risk factor for T2D, is mainly …

[HTML][HTML] Associations between body composition, fat distribution and metabolic consequences of excess adiposity with severe COVID-19 outcomes: observational …

M Gao, Q Wang, C Piernas, NM Astbury… - International Journal of …, 2022 - nature.com
Background Higher body mass index (BMI) and metabolic consequences of excess weight
are associated with increased risk of severe COVID-19, though their mediating pathway is …

Reversal and remission of T2DM–An update for practitioners

L Shibib, M Al-Qaisi, A Ahmed, AD Miras… - Vascular Health and …, 2022 - Taylor & Francis
Over the past 50 years, many countries around the world have faced an unchecked
pandemic of obesity and type 2 diabetes (T2DM). As best practice treatment of T2DM has …

[HTML][HTML] Proteomics and phosphoproteomics of circulating extracellular vesicles provide new insights into diabetes pathobiology

YO Nunez Lopez, A Iliuk, AM Petrilli, C Glass… - International journal of …, 2022 - mdpi.com
The purpose of this study was to define the proteomic and phosphoproteomic landscape of
circulating extracellular vesicles (EVs) in people with normal glucose tolerance (NGT) …

Fat distribution within the pancreas according to diabetes status and insulin traits

L Skudder-Hill, IR Sequeira, J Cho, J Ko, SD Poppitt… - Diabetes, 2022 - Am Diabetes Assoc
A growing body of evidence suggests that intrapancreatic fat is associated with diabetes, but
whether distribution of intrapancreatic fat across the regions of the pancreas has a …

[HTML][HTML] Galectin-1 in obesity and type 2 diabetes

E Fryk, VRR Silva, PA Jansson - Metabolites, 2022 - mdpi.com
Galectin-1 is a carbohydrate-binding protein expressed in many tissues. In recent years,
increasing evidence has emerged for the role of galectin-1 in obesity, insulin resistance and …

[HTML][HTML] Not control but conquest: strategies for the remission of type 2 diabetes mellitus

J Kim, HS Kwon - Diabetes & metabolism journal, 2022 - synapse.koreamed.org
A durable normoglycemic state was observed in several studies that treated type 2 diabetes
mellitus (T2DM) patients through metabolic surgery, intensive therapeutic intervention, or …

[HTML][HTML] Remission as an emerging therapeutic target in type 2 diabetes in the era of New glucose-lowering agents: Benefits, challenges, and treatment approaches

D Vasdeki, T Koufakis, G Tsamos, L Busetto… - Nutrients, 2022 - mdpi.com
Type 2 diabetes mellitus (T2DM) is a progressive disease with a growing prevalence,
associated with an increased risk of complications. The introduction of new classes of …