Osteoporosis is a skeletal disorder with enhanced bone fragility, usually affecting the elderly.
It is very rare in children and young adults and the definition is not only based on a low BMD …

The advancement of human genomics has revolutionized our understanding of the genetic
architecture of many skeletal diseases, including osteoporosis. However, interpreting results …

Osteoporosis in premenopausal women with intact gonadal function and no known
secondary cause of bone loss is termed idiopathic osteoporosis (IOP). Women with IOP …

Bone science has over the last decades unraveled many important pathways in bone and
mineral metabolism and the interplay between genetic factors and the environment. Some of …

The earliest reports of atypical femur fractures (AFF) emerged from Asia. In the West,
epidemiologic studies report a greater incidence of AFFs among subjects of Asian …

Atypical femur fractures (AFFs) are rare complications of anti resorptive therapy. Devastating
to the affected individual, they pose a public health concern because of reduced uptake of …

Atypical femoral fractures (AFF) are rare fragility fractures in the subtrocantheric or diaphysis
femoral region associated with long-term bisphosphonate (BP) treatment. The etiology of …

Abstract Context Atypical femoral fractures (AFFs) are very rare atraumatic or mild trauma
fractures in the subtrochanteric region or femoral shaft. Some unique genetic variants in …

Hypophosphatasia (HPP) is a rare genetic disorder characterized by low serum alkaline
phosphatase (ALP), its manifestations may include atypical femoral fractures (AFF) …

Context Hypophosphatasia (HPP) is a rare metabolic disorder caused by deficiency of
alkaline phosphatase (ALP) enzyme activity, leading to defective mineralization, due to …