The tumor microenvironment (TME) is a heterogeneous, complex organization composed of
tumor, stroma, and endothelial cells that is characterized by cross talk between tumor and …

Adipose tissue is a complex dynamic organ with whole-body immunometabolic influence.
Much of the work into understanding the role of immune cells in adipose tissue has been in …

CXCL13 is a B-cell chemokine produced mainly by mesenchymal lymphoid tissue organizer
cells, follicular dendritic cells, and human T follicular helper cells. By binding to its receptor …

Chemokine CXC motif ligand 13 (CXCL13), originally identified as a B-cell chemokine, plays
an important role in the immune system. The interaction between CXCL13 and its receptor …

Obesity increases the risk of type 2 diabetes mellitus, cardiovascular disease, fatty liver
disease, and cancer. It is also linked with more severe complications from infections …

Background The path to childhood asthma is thought to initiate in utero and be further
promoted by postnatal exposures. However, the underlying mechanisms remain …

The immune response of the adipose tissue (AT) has been neglected in most animal models
until investigations in human and mice linked obesity to chronic inflammation, highlighting …

B-cell chronic lymphocytic leukemia (CLL) results from intrinsic genetic defects and complex
microenvironment stimuli that fuel CLL cell growth through an array of survival signaling …

Due to the vital roles of macrophages in the pathogenesis of endometriosis, targeting
macrophages could be a promising therapeutic direction. Here, we investigated the efficacy …

In the peritoneal cavity, the omentum contains fat-associated lymphoid clusters (FALCs)
whose role in response to infection is poorly understood. After intraperitoneal immunization …