[HTML][HTML] A large-scale genome-wide gene-gene interaction study of lung cancer susceptibility in Europeans with a trans-ethnic validation in Asians

R Zhang, S Shen, Y Wei, Y Zhu, Y Li, J Chen… - Journal of Thoracic …, 2022 - Elsevier
Introduction Although genome-wide association studies have been conducted to investigate
genetic variation of lung tumorigenesis, little is known about gene-gene (G× G) interactions …

Lyz2-Cre-Mediated Genetic Deletion of Septin7 Reveals a Role of Septins in Macrophage Cytokinesis and Kras-Driven Tumorigenesis

MB Menon, T Yakovleva, N Ronkina… - Frontiers in cell and …, 2022 - frontiersin.org
By crossing septin7-floxed mice with Lyz2-Cre mice carrying the Cre recombinase inserted
in the Lysozyme-M (Lyz2) gene locus we aimed the specific deletion of septin7 in myeloid …

Epigenome-wide gene–age interaction study reveals reversed effects of MORN1 DNA methylation on survival between young and elderly oral squamous cell …

Z Xu, Y Gu, J Chen, X Chen, Y Song, J Fan, X Ji… - Frontiers in …, 2022 - frontiersin.org
DNA methylation serves as a reversible and prognostic biomarker for oral squamous cell
carcinoma (OSCC) patients. It is unclear whether the effect of DNA methylation on OSCC …

Integrative Approaches to Analyze Cancer Based on Multi‐Omics

S Shen - Frontiers in Genetics, 2022 - frontiersin.org
Cancer is a multifactorial malignant disease driven by environmental exposure, genetic
polymorphism, somatic mutation events, and other downstream omics (Shen et al., 2021a; …