The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …

Inherited cardiomyopathies are a major cause of mortality and morbidity worldwide and can
be caused by mutations in a wide range of proteins located in different cellular …

Aims Gain-of-function mutations in RYR2, encoding the cardiac ryanodine receptor channel
(RyR2), cause catecholaminergic polymorphic ventricular tachycardia (CPVT). Whereas …

Importance Calcium-release deficiency syndrome (CRDS), which is caused by loss-of-
function variants in cardiac ryanodine receptor 2 (RyR2), is an emerging cause of ventricular …

Sudden death is a rare event in the pediatric population but with a social shock due to its
presentation as the first symptom in previously healthy children. Comprehensive autopsy in …

Cardiovascular disease (CVD) continues to be the most common cause of death worldwide,
and cardiac arrhythmias account for approximately one half of these deaths. The morbidity …

Mutations of the RyR2 are channelopathies that can predispose to life threatening
catecholaminergic polymorphic ventricular tachycardias (CPVTs) during exercise or stress …

Abstract Purpose of the Review Left ventricular non-compaction (LVNC) is characterised by
prominent left ventricular trabeculae and deep inter-trabecular recesses. Although …

The original version of this article contained a mistake. During the eproofing procedure, the
authors found that the entire 74 references of the 2 tables were not included. All these …

The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …