[HTML][HTML] Molecular Landscape of LncRNAs in Prostate Cancer: A focus on pathways and therapeutic targets for intervention
S Mirzaei, MDA Paskeh, E Okina, MH Gholami… - Journal of Experimental …, 2022 - Springer
Background One of the most malignant tumors in men is prostate cancer that is still incurable
due to its heterogenous and progressive natures. Genetic and epigenetic changes play …
due to its heterogenous and progressive natures. Genetic and epigenetic changes play …
Current challenges in understanding the role of enhancers in disease
Enhancers play a central role in the spatiotemporal control of gene expression and tend to
work in a cell-type-specific manner. In addition, they are suggested to be major contributors …
work in a cell-type-specific manner. In addition, they are suggested to be major contributors …
A histidine cluster determines YY1-compartmentalized coactivators and chromatin elements in phase-separated enhancer clusters
W Wang, S Qiao, G Li, J Cheng, C Yang… - Nucleic acids …, 2022 - academic.oup.com
As an oncogenic transcription factor, Yin Yang 1 (YY1) regulates enhancer and promoter
connection. However, gaps still exist in understanding how YY1 coordinates coactivators …
connection. However, gaps still exist in understanding how YY1 coordinates coactivators …
Long non-coding RNAs (lncRNAs); roles in tumorigenesis and potentials as biomarkers in cancer diagnosis
S Najafi, SH Khatami, M Khorsand, Z Jamali… - Experimental cell …, 2022 - Elsevier
New research has indicated that long non-coding RNAs (lncRNAs) play critical roles in a
broad range of biological processes, including the pathogenesis of many complex human …
broad range of biological processes, including the pathogenesis of many complex human …
[HTML][HTML] Long non-coding RNAs: novel regulators of cellular physiology and function
JA Oo, RP Brandes, MS Leisegang - Pflügers Archiv-European Journal of …, 2022 - Springer
Long non-coding RNAs were once considered as “junk” RNA produced by aberrant DNA
transcription. They are now understood to play central roles in diverse cellular processes …
transcription. They are now understood to play central roles in diverse cellular processes …
[HTML][HTML] Complexities of prostate cancer
Prostate cancer has a long disease history and a wide variety and uncertainty in individual
patients' clinical progress. In recent years, we have seen a revolutionary advance in both …
patients' clinical progress. In recent years, we have seen a revolutionary advance in both …
The lncRNA NEAT1/miRNA‐766‐5p/E2F3 regulatory axis promotes prostate cancer progression
W Zhao, X Zhu, Q Jin, B Lin, R Ji - Journal of oncology, 2022 - Wiley Online Library
Background. Prostate cancer (PCa) is one of the most common malignancies in men.
Increasing evidence has demonstrated that dysregulation of long noncoding RNAs …
Increasing evidence has demonstrated that dysregulation of long noncoding RNAs …
[HTML][HTML] SNP-target genes interaction perturbing the cancer risk in the post-GWAS
W Yang, T Zhang, X Song, G Dong, L Xu, F Jiang - Cancers, 2022 - mdpi.com
Simple Summary Genome-wide association studies have identified a vast number of cancer
risk-associated loci harboring numerous single nucleotide polymorphisms that regulate …
risk-associated loci harboring numerous single nucleotide polymorphisms that regulate …
[HTML][HTML] ALKBH5-mediated N6-methyladenosine modification of TRERNA1 promotes DLBCL proliferation via p21 downregulation
W Song, F Fei, F Qiao, Z Weng, Y Yang, B Cao… - Cell Death …, 2022 - nature.com
Long noncoding RNAs (lncRNAs) have crucial functions in the tumorigenesis and
metastasis of cancers. N6-methyladenosine (m6A) modification of RNA is an important …
metastasis of cancers. N6-methyladenosine (m6A) modification of RNA is an important …
LINC00624/TEX10/NF-κB axis promotes proliferation and migration of human prostate cancer cells
J Zhou, J Li, C Qian, F Qiu, Q Shen, R Tong… - Biochemical and …, 2022 - Elsevier
Prostate cancer (PCa) is a malignant epithelial tumor with a high rate of biochemical or local
recurrence. Studies have suggested that LINC00624 plays an important oncogenic role in …
recurrence. Studies have suggested that LINC00624 plays an important oncogenic role in …