As the most prevalent form of arrhythmia, atrial fibrillation (AF) increases the risk of heart
failure, thromboembolism, and stroke, contributing to the raising mortality and morbidity in …

Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although
recent advances in cell-based models, including human-induced pluripotent stem cell …

Background: Cardiac ischemia/reperfusion (I/R) injury has emerged as an important
therapeutic target for ischemic heart disease, the leading cause of morbidity and mortality …

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases regulate production of
reactive oxygen species (ROS) that cause oxidative damage to cellular components but also …

Arterial hypertension affects≈ 1 billion people worldwide. It is associated with increased
morbidity and mortality and responsible for millions of deaths each year. Hypertension …

Atrial fibrillation (AF), the most common cardiac arrhythmia worldwide, is driven by complex
mechanisms that differ between subgroups of patients. This complexity is apparent from the …

Calcium/calmodulin-dependent protein kinase II δ (CaMKIIδ) has a pivotal role in cardiac
signaling. Constitutive and deleterious CaMKII" autonomous" activation is induced by …

Cardiac arrhythmia occurs frequently worldwide, and in severe cases can be fatal.
Mitochondria are the power plants of cardiomyocytes. In recent studies, mitochondria under …

Abstract Aims Abnormal intracellular calcium (Ca2+) handling contributes to the progressive
nature of atrial fibrillation (AF), the most common sustained cardiac arrhythmia. Evidence in …

Mice are routinely used to investigate molecular mechanisms underlying the atrial fibrillation
(AF) substrate. We sought to optimize transesophageal rapid atrial pacing (RAP) protocols …