Ageing and chronic degenerative pathologies demonstrate the shared characteristics of
high bioavailability of reactive oxygen species (ROS) and oxidative stress, chronic/persistent …

Ischemic heart disease (IHD) is the leading cause of disability and mortality worldwide.
Reactive oxygen species (ROS) have been shown to play key roles in the progression of …

Vascular smooth muscle cells (VSMCs), the major cell type in the arterial vessel wall, have a
contractile phenotype that maintains the normal vessel structure and function under …

It is well known that cardiovascular disease manifests differently in women and men. The
underlying causes of these differences during the aging lifespan are less well understood …

Microcirculation and macrocirculation are tightly interconnected into a dangerous cross-link
in hypertension. Small artery damage includes functional (vasoconstriction, impaired …

Aortic dimensions and distensibility are key risk factors for aortic aneurysms and dissections,
as well as for other cardiovascular and cerebrovascular diseases. We present genome-wide …

Aortic stiffness increases with advancing age, more than doubling during the human life
span, and is a robust predictor of cardiovascular disease (CVD) clinical events independent …

Blood vessels are subjected to mechanical loads of pressure and flow, inducing smooth
muscle circumferential and endothelial shear stresses. The perception and response of …

The aging population is booming all over the world and arterial aging causes various age-
associated pathologies such as cardiovascular diseases (CVDs). The aorta is the largest …

Rationale: Vascular smooth muscle cells (VSMCs) phenotype switch from contractile to
proliferative phenotype is a pathological hallmark in various cardiovascular diseases …