Features and factors that dictate if terminating ribosomes cause or counteract nonsense-mediated mRNA decay
CM Embree, R Abu-Alhasan, G Singh - Journal of Biological Chemistry, 2022 - ASBMB
Nonsense-mediated mRNA decay (NMD) is a quality control pathway in eukaryotes that
continuously monitors mRNA transcripts to ensure truncated polypeptides are not produced …
continuously monitors mRNA transcripts to ensure truncated polypeptides are not produced …
No-nonsense: insights into the functional interplay of nonsense-mediated mRNA decay factors
J Mailliot, M Vivoli-Vega, C Schaffitzel - Biochemical Journal, 2022 - portlandpress.com
Nonsense-mediated messenger RNA decay (NMD) represents one of the main surveillance
pathways used by eukaryotic cells to control the quality and abundance of mRNAs and to …
pathways used by eukaryotic cells to control the quality and abundance of mRNAs and to …
Mammalian UPF3A and UPF3B can activate nonsense‐mediated mRNA decay independently of their exon junction complex binding
Z Yi, RM Arvola, S Myers, CN Dilsavor… - The EMBO …, 2022 - embopress.org
Nonsense‐mediated mRNA decay (NMD) is governed by the three conserved factors—
UPF1, UPF2, and UPF3. While all three are required for NMD in yeast, UPF3B is …
UPF1, UPF2, and UPF3. While all three are required for NMD in yeast, UPF3B is …
Human UPF3A and UPF3B enable fault‐tolerant activation of nonsense‐mediated mRNA decay
D Wallmeroth, JW Lackmann, S Kueckelmann… - The EMBO …, 2022 - embopress.org
The paralogous human proteins UPF3A and UPF3B are involved in recognizing mRNAs
targeted by nonsense‐mediated mRNA decay (NMD). UPF3B has been demonstrated to …
targeted by nonsense‐mediated mRNA decay (NMD). UPF3B has been demonstrated to …
The role of altered translation in intellectual disability and epilepsy
TJ Malone, LK Kaczmarek - Progress in neurobiology, 2022 - Elsevier
A very high proportion of cases of intellectual disability are genetic in origin and are
associated with the occurrence of epileptic seizures during childhood. These two disorders …
associated with the occurrence of epileptic seizures during childhood. These two disorders …
Structures of nonsense-mediated mRNA decay factors UPF3B and UPF3A in complex with UPF2 reveal molecular basis for competitive binding and for …
JC Bufton, KT Powers, JYA Szeto… - Nucleic acids …, 2022 - academic.oup.com
UPF3 is a key nonsense-mediated mRNA decay (NMD) factor required for mRNA
surveillance and eukaryotic gene expression regulation. UPF3 exists as two paralogs (A and …
surveillance and eukaryotic gene expression regulation. UPF3 exists as two paralogs (A and …
Diverse roles of the exon junction complex factors in the cell cycle, cancer, and neurodevelopmental disorders-potential for therapeutic targeting
H Martin, J Rupkey, S Asthana, J Yoon, S Patel… - International journal of …, 2022 - mdpi.com
The exon junction complex (EJC) plays a crucial role in regulating gene expression at the
levels of alternative splicing, translation, mRNA localization, and nonsense-mediated decay …
levels of alternative splicing, translation, mRNA localization, and nonsense-mediated decay …
Molecular basis of neurodevelopmental disorder-causing mutation in nonsense-mediated mRNA decay factor UPF3B
JC Bufton, KT Powers, JYA Szeto, C Schaffitzel - bioRxiv, 2022 - biorxiv.org
ABSTRACT UPF3B is a key nonsense-mediated mRNA decay (NMD) factor required for
surveillance of mRNA and regulation of eukaryotic gene expression. Mutations in UPF3B …
surveillance of mRNA and regulation of eukaryotic gene expression. Mutations in UPF3B …
Impact sur la relation hôte-pathogène de l'interaction entre l'hélicase UPF1 et les transporteurs rétroviraux, Rex d'HTLV-1 et Rev d'HIV-1
L Prochasson - 2022 - theses.hal.science
De par son rôle central dans plusieurs voies de dégradation de l'ARN, l'hélicase UPF1 (UP-
Frameshift 1) est associée à différents processus cellulaires contrôlant la stabilité de l'ARN …
Frameshift 1) est associée à différents processus cellulaires contrôlant la stabilité de l'ARN …
Impact of protein-protein interactions and phosphorylation on RNA decapping for nonsense mediated mRNA decay (NMD)
A Gilbert - 2022 - theses.hal.science
In yeast, mRNA degradation is mainly initiated through the cleavage of the pyrophosphate
bond between the mRNA and the cap structure at its 5'-end. While this step is important for …
bond between the mRNA and the cap structure at its 5'-end. While this step is important for …