[HTML][HTML] Colorectal cancer-infiltrating regulatory T cells: functional heterogeneity, metabolic adaptation, and therapeutic targeting
S Aristin Revilla, O Kranenburg, PJ Coffer - Frontiers in immunology, 2022 - frontiersin.org
Colorectal cancer (CRC) is a heterogeneous disease with one of the highest rates of
incidence and mortality among cancers worldwide. Understanding the CRC tumor …
incidence and mortality among cancers worldwide. Understanding the CRC tumor …
News on immune checkpoint inhibitors as immunotherapy strategies in adult and pediatric solid tumors
O Melaiu, V Lucarini, R Giovannoni, D Fruci… - Seminars in cancer …, 2022 - Elsevier
Immune checkpoint inhibitors (ICIs) have shown unprecedented benefits in various adult
cancers, and this success has prompted the exploration of ICI therapy even in childhood …
cancers, and this success has prompted the exploration of ICI therapy even in childhood …
[HTML][HTML] Colorectal cancer and purinergic signalling: an overview
GG Roliano, JH Azambuja, VT Brunetto, HE Butterfield… - Cancers, 2022 - mdpi.com
Highlights What are the main findings? CD39-CD73 axis in tumor-associated immune cells
promotes immune exhaustion, impairment of antitumor immune activity, and increased CRC …
promotes immune exhaustion, impairment of antitumor immune activity, and increased CRC …
[HTML][HTML] Associations of different immune checkpoints-expressing CD4+ Treg/ T cell subsets with disease-free survival in colorectal cancer patients
There are different subsets of T regulatory cells (Tregs), orchestrating critical roles in the
regulation of anti-tumor immunity in colorectal cancer (CRC). In this study, we report that a …
regulation of anti-tumor immunity in colorectal cancer (CRC). In this study, we report that a …
[HTML][HTML] Stratification of chemotherapy-treated stage III colorectal cancer patients using multiplexed imaging and single-cell analysis of T-cell populations
X Stachtea, MB Loughrey, M Salvucci, AU Lindner… - Modern …, 2022 - nature.com
Colorectal cancer (CRC) has one of the highest cancer incidences and mortality rates. In
stage III, postoperative chemotherapy benefits< 20% of patients, while more than 50% will …
stage III, postoperative chemotherapy benefits< 20% of patients, while more than 50% will …
Upregulated TIGIT+ and Helios+ regulatory T cell levels in bronchoalveolar lavage fluid of NSCLC patients
F Lin, X Hu, Y Zhang, S Ye, Y Gu, B Yan, L Wang… - Molecular …, 2022 - Elsevier
Background The tumour microenvironment reshapes the specific gene expression of
regulatory T cells (Tregs). A better definition of Treg subpopulations in the non-small-cell …
regulatory T cells (Tregs). A better definition of Treg subpopulations in the non-small-cell …
[HTML][HTML] Analysis of ARHGAP4 expression with colorectal cancer clinical characteristics and prognosis
M Fu, S Pan, X Cai, Y Hu, W Zhang, Q Pan - Frontiers in oncology, 2022 - frontiersin.org
Background This study aims to analyze the correlation between ARHGAP4 in the expression
and clinical characteristics of colorectal cancer (CRC), and the influence of ARHGAP4 …
and clinical characteristics of colorectal cancer (CRC), and the influence of ARHGAP4 …
[HTML][HTML] Correlations between Circulating and Tumor-Infiltrating CD4+ Treg Subsets with Immune Checkpoints in Colorectal Cancer Patients with Early and Advanced …
The existence of various T regulatory cell (Treg) subsets in colorectal cancer (CRC) could
play a variety of functions in the regulation of anti-cancer immunity. We studied correlations …
play a variety of functions in the regulation of anti-cancer immunity. We studied correlations …
[HTML][HTML] Correlations between Circulating and Tumor-Infiltrating CD4+ T Cell Subsets with Immune Checkpoints in Colorectal Cancer
T regulatory cells (Tregs) play different roles in the regulation of anti-tumor immunity in
colorectal cancer (CRC), depending on the presence of different Treg subsets. We …
colorectal cancer (CRC), depending on the presence of different Treg subsets. We …
[HTML][HTML] 活性氧对肿瘤免疫检查点的调控作用及机制研究进展
李晓风， 王圆， 韦淑颖， 邹伟， 罗欣， 李佳怡， 韦忠红… - 药学学报, 2022 - html.rhhz.net
免疫检查点(immune checkpoints, ICs) 是一类在免疫细胞上表达的免疫抑制性分子,
能调节免疫激活程度. 免疫检查点抑制剂(immune checkpoint inhibitors, ICIs) …
能调节免疫激活程度. 免疫检查点抑制剂(immune checkpoint inhibitors, ICIs) …