Mechanistic Understanding of KOtBu‐Mediated Direct Amidation of Esters with Anilines: An Experimental Study and Computational Approach
A sustainable and cost‐effective protocol has been reported for the synthesis of amide
bonds from unactivated esters and non‐nucleophilic amines promoted by potassium tert …
bonds from unactivated esters and non‐nucleophilic amines promoted by potassium tert …
Development of a Robust and Scalable Synthetic Route for a Potent and Selective Isoindolinone PI3Kγ Inhibitor
We recently described the structure-guided optimization of a series of pyrazolopyrimidine
isoindolinone PI3Kγ inhibitors, which resulted in the identification of an advanced lead …
isoindolinone PI3Kγ inhibitors, which resulted in the identification of an advanced lead …