CIC-DUX4 sarcomas : Current Opinion in Oncology CIC-DUX4 sarcomas : Current Opinion in
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Cuproptosis is a new type of cell death that is associated with mitochondrial respiration of
the tricarboxylic acid cycle. Previous studies showed that long non-coding RNAs (lncRNAs) …

Capicua (CIC)'s transcriptional repressor function is implicated in neurodevelopment and in
oligodendroglioma (ODG) aetiology. However, CIC's role in these contexts remains obscure …

Targeting lineage-defined transcriptional dependencies has emerged as an effective
therapeutic strategy in cancer treatment. Through screening for molecular vulnerabilities of …

Neural tube defects (NTDs) are congenital malformations resulting from abnormal
embryonic development of the brain, spine, or spinal column. The genetic etiology of human …

Heterozygous pathogenic variants in CIC, which encodes a transcriptional repressor, have
been identified in individuals with neurodevelopmental phenotypes. To date, 11 CIC …

Extracellular signal-related kinase (ERK) regulates gene expression through substrate
phosphorylation. The conserved transcriptional repressor Capicua (CIC) is negatively …

Résumé Les gliomes constituent le groupe de tumeurs cérébrales malignes le plus fréquent.
Toutefois, nous connaissons partiellement les mécanismes à l'origine de leur …