Glutathione peroxidase 4 (GPX4) is one of the most important antioxidant enzymes. As the
key regulator of ferroptosis, GPX4 has attracted considerable attention in the fields of cancer …

Many diseases are driven by proteins that are aberrantly ubiquitinated and degraded. These
diseases would be therapeutically benefited by targeted protein stabilization (TPS). Here we …

Proteolysis-targeting chimeras (PROTACs), heterobifunctional compounds that consist of
protein-targeting ligands linked to an E3 ligase recruiter, have arisen as a powerful …

Aberrant microbe-immune cell interaction is a predisposing factor in inflammatory bowel
disease (IBD) and colitis-associated cancer (CAC). Cortex Periplocae is a famous traditional …

Abstract Background Glutathione Peroxidase 4 (GPX4) is a key protein that inhibits
ferroptosis. However, its biological regulation and mechanism in endometrial cancer (EC) …

Covalent inhibitors of enzymes are increasingly appreciated as pharmaceutical seeds, yet
discovering non-cysteine-targeting inhibitors remains challenging. Herein, we report an …

Protein phosphatase 2A (PP2A) is a family of serine threonine phosphatases responsible for
regulating protein phosphorylation, thus opposing the activity of cellular kinases. PP2A is …

Withaferin A, a natural steroidal lactone found in the extracts of Withania somnifera, is used
extensively in traditional medicine and part of an ancient remedy in ayurvedic medicine …

Covalent drugs incorporate a mildly electrophilic functional group that reacts with protein
targets to confer additional affinity beyond the non-covalent interactions involved in drug …

Modern small molecule drug discovery is dominated, and subsequently limited by a
paradigm of reversible non-covalent inhibitors. The deubiquitinating enzymes (DUBs) is a …