Mammalian genomes express two principal gene categories through RNA polymerase II-
mediated transcription: protein-coding transcription units and non-coding RNA transcription …

The identification and characterization of cis-regulatory DNA sequences and how they
function to coordinate responses to developmental and environmental cues is of paramount …

Abstract Non-coding RNAs (ncRNAs), which occupy the vast majority of human transcripts
are known for their inability to encode proteins. NcRNAs consist of a diverse range of RNA …

Do long noncoding RNAs (lncRNAs) contribute little or substantively to human biology? To
address how lncRNA loci and their transcripts, structures, interactions, and functions …

Cohesin and CTCF are major drivers of 3D genome organization, but their role in neurons is
still emerging. Here, we show a prominent role for cohesin in the expression of genes that …

Identification of risk variants for neuropsychiatric diseases within enhancers underscores the
importance of understanding population-level variation in enhancer function in the human …

MicroRNAs (miRNAs) are small noncoding RNAs that play an important role in regulating
gene expression at a posttranscriptional level. As one of the first discovered oncogenic …

Adolescent binge drinking is a major risk factor for psychiatric disorders later in life including
alcohol use disorder. Adolescent alcohol exposure induces epigenetic reprogramming at …

Nuclear deformation, a hallmark frequently observed in senescent cells, is presumed to be
associated with the erosion of chromatin organization at the nuclear periphery. However …

The regulation of RNA polymerase II (pol II) transcription requires a complex and context-
specific array of proteins and protein complexes, as well as nucleic acids and metabolites …