Systemic sclerosis–associated interstitial lung disease: How to incorporate two food and drug administration–approved therapies in clinical practice
Systemic sclerosis (SSc; scleroderma) has the highest individual mortality of all rheumatic
diseases, and interstitial lung disease (ILD) is among the leading causes of SSc‐related …
diseases, and interstitial lung disease (ILD) is among the leading causes of SSc‐related …
Clinical treatment options in scleroderma: recommendations and comprehensive review
M Zhao, J Wu, H Wu, AH Sawalha, Q Lu - Clinical Reviews in Allergy & …, 2022 - Springer
There are two major clinical subsets of scleroderma:(i) systemic sclerosis (SSc) is a complex
systemic autoimmune disorder characterized by inflammation, vasculopathy, and excessive …
systemic autoimmune disorder characterized by inflammation, vasculopathy, and excessive …
[HTML][HTML] Systemic sclerosis: from pathophysiology to novel therapeutic approaches
D Benfaremo, S Svegliati, C Paolini, S Agarbati… - Biomedicines, 2022 - mdpi.com
Systemic sclerosis (SSc) is a systemic, immune-mediated chronic disorder characterized by
small vessel alterations and progressive fibrosis of the skin and internal organs. The …
small vessel alterations and progressive fibrosis of the skin and internal organs. The …
[HTML][HTML] The efficacy and safety of pirfenidone combined with immunosuppressant therapy in connective tissue disease-associated interstitial lung disease: a 24-week …
J Wang, X Wang, X Qi, Z Sun, T Zhang, Y Cui… - Frontiers in …, 2022 - frontiersin.org
Objective Interstitial lung disease (ILD) is a common manifestation of connective tissue
disease (CTD) that manifests as several subtypes with significant differences in prognosis. It …
disease (CTD) that manifests as several subtypes with significant differences in prognosis. It …
[HTML][HTML] Pirfenidone for idiopathic pulmonary fibrosis and beyond
A Aimo, G Spitaleri, D Nieri, LM Tavanti… - Cardiac Failure …, 2022 - ncbi.nlm.nih.gov
Pirfenidone (PFD) slows the progression of idiopathic pulmonary fibrosis (IPF) by inhibiting
the exaggerated fibrotic response and possibly through additional mechanisms, such as anti …
the exaggerated fibrotic response and possibly through additional mechanisms, such as anti …
Management of progressive pulmonary fibrosis associated with connective tissue disease
M Molina-Molina, I Castellví, C Valenzuela… - Expert Review of …, 2022 - Taylor & Francis
Introduction Fibrotic interstitial lung disease (ILD) is a frequent and severe complication of
connective tissue disease (CTD). Areas covered In this narrative review, we update the most …
connective tissue disease (CTD). Areas covered In this narrative review, we update the most …
[HTML][HTML] Management of connective tissue disease–related interstitial lung disease
S Ahmed, R Handa - Current Pulmonology Reports, 2022 - Springer
Abstract Purpose of Review This review aims to collate current evidence on the screening,
diagnosis, and treatment of various connective tissue disease (CTD)–associated interstitial …
diagnosis, and treatment of various connective tissue disease (CTD)–associated interstitial …
[HTML][HTML] Therapeutic options for systemic sclerosis: current and future perspectives in tackling immune-mediated fibrosis
TI Papadimitriou, A van Caam, PM van der Kraan… - Biomedicines, 2022 - mdpi.com
Systemic sclerosis (SSc) is a severe auto-immune, rheumatic disease, characterized by
excessive fibrosis of the skin and visceral organs. SSc is accompanied by high morbidity …
excessive fibrosis of the skin and visceral organs. SSc is accompanied by high morbidity …
Systemic sclerosis in adults. Part II: management and therapeutics
R Jerjen, M Nikpour, T Krieg, CP Denton… - Journal of the American …, 2022 - Elsevier
The management of systemic sclerosis (SSc) is complex, evolving, and requires a
multidisciplinary approach. At diagnosis and throughout the disease course, clinical …
multidisciplinary approach. At diagnosis and throughout the disease course, clinical …
[HTML][HTML] Pirfenidone exacerbates Th2-driven vasculopathy in a mouse model of systemic sclerosis-associated interstitial lung disease
A Birnhuber, K Jandl, V Biasin, E Fließer… - European …, 2022 - Eur Respiratory Soc
Background Systemic sclerosis (SSc) is an autoimmune disease characterised by severe
vasculopathy and fibrosis of various organs including the lung. Targeted treatment options …
vasculopathy and fibrosis of various organs including the lung. Targeted treatment options …