RONS and oxidative stress: An overview of basic concepts

AK Aranda-Rivera, A Cruz-Gregorio… - Oxygen, 2022 - mdpi.com
Oxidative stress (OS) has greatly interested the research community in understanding
damaging processes occurring in cells. OS is triggered by an imbalance between reactive …

Molecular mechanism of lipotoxicity as an interesting aspect in the development of pathological states—current view of knowledge

K Lipke, A Kubis-Kubiak, A Piwowar - Cells, 2022 - mdpi.com
Free fatty acids (FFAs) play numerous vital roles in the organism, such as contribution to
energy generation and reserve, serving as an essential component of the cell membrane, or …

[HTML][HTML] Hypothalamic astrocytes control systemic glucose metabolism and energy balance

DHM Chao, MK Kirchner, C Pham, E Foppen… - Cell metabolism, 2022 - cell.com
The hypothalamus is key in the control of energy balance. However, strategies targeting
hypothalamic neurons have failed to provide viable options to treat most metabolic diseases …

Obesity and dietary fat influence dopamine neurotransmission: Exploring the convergence of metabolic state, physiological stress, and inflammation on dopaminergic …

CW Wallace, SC Fordahl - Nutrition research reviews, 2022 - cambridge.org
The aim of this review is to explore how metabolic changes induced by diets high in
saturated fat (HFD) affect nucleus accumbens (NAc) dopamine neurotransmission and food …

Dietary fatty acid intake and the colonic gut microbiota in humans

AA Xu, LK Kennedy, K Hoffman, DL White, F Kanwal… - Nutrients, 2022 - mdpi.com
A high-fat diet has been associated with systemic diseases in humans and alterations in gut
microbiota in animal studies. However, the influence of dietary fatty acid intake on gut …

Hypothalamic inflammation in metabolic disorders and aging

A Bhusal, MH Rahman, K Suk - Cellular and molecular life sciences, 2022 - Springer
The hypothalamus is a critical brain region for the regulation of energy homeostasis. Over
the years, studies on energy metabolism primarily focused on the neuronal component of …

Hydrogen sulfide attenuates high-fat diet-induced obesity: Involvement of mTOR/IKK/NF-κB signaling pathway

M Zhao, Y Cheng, X Wang, X Cui, X Cheng, Q Fu… - Molecular …, 2022 - Springer
Obesity has become a public health epidemic worldwide and is associated with many
diseases with high mortality including hypertension, diabetes, and heart disease. High-fat …

The role of hypothalamic endoplasmic reticulum stress in schizophrenia and antipsychotic-induced weight gain: A narrative review

R Zhou, M He, J Fan, R Li, Y Zuo, B Li, G Gao… - Frontiers in …, 2022 - frontiersin.org
Schizophrenia (SCZ) is a serious mental illness that affects 1% of people worldwide. SCZ is
associated with a higher risk of developing metabolic disorders such as obesity …

[HTML][HTML] High fat diet-induced brain damaging effects through autophagy-mediated senescence, inflammation and apoptosis mitigated by ginsenoside F1-enhanced …

J Hou, B Jeon, J Baek, Y Yun, D Kim, B Chang… - Journal of Ginseng …, 2022 - Elsevier
Abstracts Background Herbal medicines are popular approaches to capably prevent and
treat obesity and its related diseases. Excessive exposure to dietary lipids causes oxidative …

Immunoinflammatory processes: Overlapping mechanisms between obesity and eating disorders?

E Breton, JF Soh, L Booij - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
Obesity and eating disorders are conditions that involve eating behaviors and are
sometimes comorbid. Current evidence supports alterations in immunoinflammatory …