Alpha-synuclein aggregates are the hallmark pathology of Parkinson's disease, which can
propagate in a stereotypical pattern along the brain-body axis. Parkinson's disease patients …

ABSTRACT α‐Synucleinopathies including idiopathic Parkinson's disease, dementia with
Lewy bodies and multiple systems atrophy share overlapping symptoms and pathological …

Parkinson's disease (PD) is the most common movement disorder, with resting tremor,
rigidity, bradykinesia and postural instability being major symptoms. Neuropathologically, it …

The therapeutic strategies currently available for neurodegenerative diseases such as
Parkinson's disease target only the symptoms of the disease. Parkinson's disease, dementia …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive
movement disability accompanied by non‐motor symptoms. The neuropathology hallmark of …

Together with neuronal loss, the existence of insoluble inclusions of alpha-synuclein (α-syn)
in the brain is widely accepted as a hallmark of synucleinopathies including Parkinson's …

Amyloids are protein aggregates bearing a highly ordered cross β structural motif, which
may be functional but are mostly pathogenic. Their formation, deposition in tissues and …

Regulated cell death (RCD) is an ordered and tightly orchestrated set of changes/signaling
events in both gene expression and protein activity and is responsible for normal …

Most neurodegenerative diseases have the characteristics of protein folding disorders, ie,
they cause lesions to appear in vulnerable regions of the nervous system, corresponding to …

A major hallmark of Parkinson's disease (PD) is the fatal destruction of dopaminergic
neurons within the substantia nigra pars compacta. This event is preceded by the formation …