Clinical management of metastatic colorectal cancer in the era of precision medicine

F Ciardiello, D Ciardiello, G Martini… - CA: a cancer journal …, 2022 - Wiley Online Library
Colorectal cancer (CRC) represents approximately 10% of all cancers and is the second
most common cause of cancer deaths. Initial clinical presentation as metastatic CRC …

Nanodelivery of nucleic acids

BB Mendes, J Conniot, A Avital, D Yao… - Nature reviews …, 2022 - nature.com
There is growing need for a safe, efficient, specific and non-pathogenic means for delivery of
gene therapy materials. Nanomaterials for nucleic acid delivery offer an unprecedented …

[HTML][HTML] The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019

KB Tran, JJ Lang, K Compton, R Xu, AR Acheson… - The Lancet, 2022 - thelancet.com
Background Understanding the magnitude of cancer burden attributable to potentially
modifiable risk factors is crucial for development of effective prevention and mitigation …

Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

BS Sheena, L Hiebert, H Han, H Ippolito… - The lancet …, 2022 - thelancet.com
Background Combating viral hepatitis is part of the UN Sustainable Development Goals
(SDGs), and WHO has put forth hepatitis B elimination targets in its Global Health Sector …

[HTML][HTML] Age–sex differences in the global burden of lower respiratory infections and risk factors, 1990–2019: results from the Global Burden of Disease Study 2019

HH Kyu, A Vongpradith, SB Sirota… - The Lancet Infectious …, 2022 - thelancet.com
Background The global burden of lower respiratory infections (LRIs) and corresponding risk
factors in children older than 5 years and adults has not been studied as comprehensively …

Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

R Sharma, M Abbasi-Kangevari… - The lancet …, 2022 - thelancet.com
Background Colorectal cancer is the third leading cause of cancer deaths worldwide. Given
the recent increasing trends in colorectal cancer incidence globally, up-to-date information …

[HTML][HTML] The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019

EM Alvarez, LM Force, R Xu, K Compton, D Lu… - The Lancet …, 2022 - thelancet.com
Background In estimating the global burden of cancer, adolescents and young adults with
cancer are often overlooked, despite being a distinct subgroup with unique epidemiology …

[HTML][HTML] Body fatness associations with cancer: evidence from recent epidemiological studies and future directions

SC Larsson, N Spyrou, CS Mantzoros - Metabolism, 2022 - Elsevier
This narrative review highlights current evidence linking greater body fatness to risk of
various cancers, with focus on evidence from recent large cohort studies and pooled …

Identification of lung cancer breath biomarkers based on perioperative breathomics testing: A prospective observational study

P Wang, Q Huang, S Meng, T Mu, Z Liu, M He… - …, 2022 - thelancet.com
Background Breathomics testing has been considered a promising method for detection and
screening for lung cancer. This study aimed to identify breath biomarkers of lung cancer …

[HTML][HTML] Global burden of primary liver cancer in 2020 and predictions to 2040

H Rumgay, M Arnold, J Ferlay, O Lesi, CJ Cabasag… - Journal of …, 2022 - Elsevier
Background & Aims The burden of liver cancer varies across the world. Herein, we present
updated estimates of the current global burden of liver cancer (incidence and mortality) and …