[HTML][HTML] APC/C-Cdh1-targeted substrates as potential therapies for Alzheimer's disease

R Lapresa, J Agulla, JP Bolaños… - Frontiers in …, 2022 - frontiersin.org
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and the main
cause of dementia in the elderly. The disease has a high impact on individuals and their …

The anaphase-promoting complex/Cyclosome is a cellular ageing regulator

X Hu, X Jin, X Cao, B Liu - International Journal of Molecular Sciences, 2022 - mdpi.com
The anaphase-promoting complex/cyclosome (APC/C) is a complicated cellular component
that plays significant roles in regulating the cell cycle process of eukaryotic organisms. The …

FAK in the nucleus prevents VSMC proliferation by promoting p27 and p21 expression via Skp2 degradation

K Jeong, JM Murphy, EYE Ahn… - Cardiovascular …, 2022 - academic.oup.com
Aims Vascular smooth muscle cells (VSMCs) normally exhibit a very low proliferative rate.
Vessel injury triggers VSMC proliferation, in part, through focal adhesion kinase (FAK) …

USP13 modulates the stability of the APC/C adaptor CDH1

M Esposito, GJ Gutierrez - Molecular Biology Reports, 2022 - Springer
Background The cell division cycle is a process that is exquisitely controlled by a complex
interplay between E3 ubiquitin ligases and deubiquitinating enzymes (DUBs). We have …

Characterization of the regulation of APC/CFZR-1 in the germline of Caenorhabditis elegans

D Puerta Martos - 2022 - gredos.usal.es
[EN] Cell cycle regulation in dividing and differentiating cells is usually studied in vitro or in
unicellular organism models. However, the C. elegans germline represents an excellent in …