Neutrophils are the most numerous cells in the leukocyte population and essential for innate
immunity. To limit their effector functions, neutrophils are able to modulate glycolysis and …

Many articles have demonstrated that extracellular neutrophil traps (NETs) are often
described as part of the antibacterial function. However, since the components of NETs are …

Age-related eye diseases, including dry eye, glaucoma, age-related macular degeneration,
and diabetic retinopathy, represent a major global health issue based on their increasing …

High salt (NaCl) concentrations are found in a number of tissues under physiological and
pathological conditions. Here, we analyzed the effects induced by high salt on the function of …

Dry eye disease (DED) is a multifactorial disorder that leads to ocular discomfort, visual
disturbance, and tear film instability. DED is accompanied by an increase in tear osmolarity …

Neutrophil extracellular traps (NETs) are net-like complexes expelled from neutrophils,
composing cell-free deoxyribonucleic acid (DNA), histones, and neutrophil granule proteins …

Dry eye is one of the most common ocular surface diseases in the world and seriously
affects the quality of life of patients. As an immune-related disease, the mechanism of dry …

Purpose The current paradigm for therapy of recalcitrant ocular surface diseases (OSD)
consists of a sequential, step-up treatment approach. A combinatorial topical therapy (anti …

Purpose: Neutrophils remain at the top of congenital and adaptive immune systems. The
past 20 years witnessed a steep rise in the interest in neutrophil extracellular traps (NETs) …

Objective: We have previously shown that neutrophil extracellular traps (NETs) are present
on the ocular surface of patients with ocular graft versus host disease (oGVHD), contributing …