Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer
To identify new susceptibility loci to lung cancer among diverse populations, we performed
cross-ancestry genome-wide association studies in European, East Asian and African …
cross-ancestry genome-wide association studies in European, East Asian and African …
Functional studies of lung cancer GWAS beyond association
Fourteen years after the first genome-wide association study (GWAS) of lung cancer was
published, approximately 45 genomic loci have now been significantly associated with lung …
published, approximately 45 genomic loci have now been significantly associated with lung …
Biology-guided precision medicine in rare cancers: Lessons from sarcomas and neuroendocrine tumours
WTA Van Der Graaf, MET Tesselaar… - Seminars in Cancer …, 2022 - Elsevier
Rare cancers, which collectively account for almost 25% of all malignancies, are poorly
understood in terms of their aetiology and pathogenesis and are infrequently the focus of …
understood in terms of their aetiology and pathogenesis and are infrequently the focus of …
[HTML][HTML] Association of smoking and polygenic risk with the incidence of lung cancer: a prospective cohort study
Background Genetic variation increases the risk of lung cancer, but the extent to which
smoking amplifies this effect remains unknown. Therefore, we aimed to investigate the risk of …
smoking amplifies this effect remains unknown. Therefore, we aimed to investigate the risk of …
[HTML][HTML] Associations of genetic risk, BMI trajectories, and the risk of non-small cell lung cancer: a population-based cohort study
D You, D Wang, Y Wu, X Chen, F Shao, Y Wei… - BMC medicine, 2022 - Springer
Background Body mass index (BMI) has been found to be associated with a decreased risk
of non-small cell lung cancer (NSCLC); however, the effect of BMI trajectories and potential …
of non-small cell lung cancer (NSCLC); however, the effect of BMI trajectories and potential …
Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes
Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL)
subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent …
subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent …
[HTML][HTML] Are polygenic risk scores ready for the cancer clinic?—a perspective
To realize the goals of precision medicine in complex disease, discriminative clinical risk
models are needed. One approach that has been proposed is polygenic risk scores (PRSs) …
models are needed. One approach that has been proposed is polygenic risk scores (PRSs) …
Identifying pleiotropic genes for complex phenotypes with summary statistics from a perspective of composite null hypothesis testing
T Wang, H Lu, P Zeng - Briefings in Bioinformatics, 2022 - academic.oup.com
Pleiotropy has important implication on genetic connection among complex phenotypes and
facilitates our understanding of disease etiology. Genome-wide association studies provide …
facilitates our understanding of disease etiology. Genome-wide association studies provide …
[HTML][HTML] Immunogenetic clustering of 30 cancers
LM James, AP Georgopoulos - Scientific reports, 2022 - nature.com
Human leukocyte antigen (HLA) genes have been implicated in cancer risk and shared
heritability of different types of cancer. In this immunogenetic epidemiological study we first …
heritability of different types of cancer. In this immunogenetic epidemiological study we first …
Pharmacogenetics in diffuse large B-cell lymphoma treated with R-CHOP: Still an unmet challenge
Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma representing
approximately one third of all non-Hodgkin lymphomas and about 40% of patients do not …
approximately one third of all non-Hodgkin lymphomas and about 40% of patients do not …