Alcoholic liver disease: a new insight into the pathogenesis of liver disease

SH Park, YS Lee, J Sim, S Seo, W Seo - Archives of Pharmacal Research, 2022 - Springer
Excessive alcohol consumption contributes to a broad clinical spectrum of liver diseases,
from simple steatosis to end-stage hepatocellular carcinoma. The liver is the primary organ …

[HTML][HTML] Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure

J Ma, A Guillot, Z Yang, B Mackowiak… - The Journal of …, 2022 - Am Soc Clin Investig
Intrahepatic neutrophil infiltration has been implicated in severe alcoholic hepatitis (SAH)
pathogenesis; however, the mechanism underlying neutrophil-induced injury in SAH …

[HTML][HTML] Advancements in the alcohol-associated liver disease model

L Zhu, HD Li, JJ Xu, JJ Li, M Cheng, XM Meng… - Biomolecules, 2022 - mdpi.com
Alcohol-associated liver disease (ALD) is an intricate disease that results in a broad
spectrum of liver damage. The presentation of ALD can include simple steatosis …

Mitochondrial depolarization after acute ethanol treatment drives mitophagy in living mice

DJ Samuvel, L Li, Y Krishnasamy, M Gooz… - Autophagy, 2022 - Taylor & Francis
Ethanol increases hepatic mitophagy driven by unknown mechanisms. Type 1 mitophagy
sequesters polarized mitochondria for nutrient recovery and cytoplasmic remodeling. In …

[HTML][HTML] Si-Wu-Tang ameliorates bile duct ligation-induced liver fibrosis via modulating immune environment

Z Ma, X Xue, J Bai, Y Cai, X Jin, K Jia, M Ding… - Biomedicine & …, 2022 - Elsevier
Abstract Si-Wu-Tang (SWT), a traditional Chinese medicine formula firstly recorded from the
Tang dynasty, has been reported to alleviate gynecological and liver diseases. We …

Tetramethylpyrazine prevents liver fibrotic injury in mice by targeting hepatocyte-derived and mitochondrial DNA-enriched extracellular vesicles

Y Li, R Liu, M Ding, Q Zheng, J Wu, X Xue… - Acta Pharmacologica …, 2022 - nature.com
Liver fibrosis is the common consequence of almost all liver diseases and has become an
urgent clinical problem without efficient therapies. Recent evidence has shown that …

Deep transfer learning for automated liver cancer gene recognition using spectrogram images of digitized DNA sequences

B Das, S Toraman - Biomedical Signal Processing and Control, 2022 - Elsevier
DNA biomarkers are considered to be an important diagnostic factor for early detection of
cancer. With the development of technology, many machine learning methods have been …

[HTML][HTML] Aldehyde accumulation in aged alcoholic beer: addressing acetaldehyde impacts on upper aerodigestive tract cancer risks

MTG Moreira, PR Pereira, A Aquino… - International journal of …, 2022 - mdpi.com
Aldehydes, particularly acetaldehyde, are carcinogenic molecules and their concentrations
in foodstuffs should be controlled to avoid upper aerodigestive tract (UADT) and liver …

ALDH2 hampers immune escape in liver hepatocellular carcinoma through ROS/Nrf2-mediated autophagy

J Hu, L Yang, X Peng, M Mao, X Liu, J Song, H Li - Inflammation, 2022 - Springer
Abstract Aldehyde dehydrogenase 2 (ALDH2) has been implicated in the progression of
liver hepatocellular carcinoma (LIHC). The most important feature of LIHC is the immune …

[HTML][HTML] HBx mediated increase of DDX17 contributes to HBV-related hepatocellular carcinoma tumorigenesis

ML Dong, X Wen, X He, JH Ren, HB Yu… - Frontiers in …, 2022 - frontiersin.org
HBV is strongly associated with HCC development and DEAD-box RNA helicase 17
(DDX17) is a very important member of the DEAD box family that plays key roles in HCC …