Background The consensus molecular subtypes (CMSs) of colorectal cancer (CRC) capture
tumor heterogeneity at the gene-expression level. Currently, a restricted number of …

Microsatellite instability (MSI) has been identified in several tumors arising from either
germline or somatic aberration. The presence of MSI in cancer predicts the sensitivity to …

A significant proportion of colorectal cancer (CRC) patients develop peritoneal metastases
(PM) in the course of their disease. PMs are associated with a poor quality of life, significant …

BRAF-mutated advanced colorectal cancer is a relatively small but critical subset of this
tumor type on the basis of prognostic and predictive implications. BRAF alterations in …

Globally, metastatic colorectal cancer is one of the leading causes for cancer-related death.
Treatment limited to conventional chemotherapeutics extended life for only a few months …

The revolution of precision medicine has produced unprecedented seismic shifts in the
treatment paradigm of advanced cancers. Among the major killers, colorectal cancer (CRC) …

Background The incidence of young-onset colorectal cancer (yoCRC) is increasing. It is
unknown if there are survival differences between young and older patients with metastatic …

Background The immunogenic nature of metastatic colorectal cancer (CRC) with high
microsatellite instability (MSI-H) underlies their responsiveness to immune checkpoint …

PURPOSE TAPUR is a phase II basket trial evaluating the antitumor activity of commercially
available targeted agents in patients with advanced cancer and genomic alterations known …

Background Patients with metastatic colorectal cancer (mCRC) carrying BRAF (mut BRAF)
or KRAS mutation (mut KRAS) have an inferior prognosis after liver or lung surgery, whereas …