Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8+ T cell immunity
M Rosás-Umbert, JD Gunst, MH Pahus… - Nature …, 2022 - nature.com
In simian-human immunodeficiency virus (SHIV)-infected non-human primates, broadly
neutralizing antibodies (bNAbs) against the virus appear to stimulate T cell immunity. To …
neutralizing antibodies (bNAbs) against the virus appear to stimulate T cell immunity. To …
Post-immune antibodies in HIV-1 infection in the context of vaccine development: a variety of biological functions and catalytic activities
A Timofeeva, S Sedykh, G Nevinsky - Vaccines, 2022 - mdpi.com
Unlike many other viruses, HIV-1 is highly variable. The structure of the viral envelope
changes as the infection progresses and is one of the biggest obstacles in developing an …
changes as the infection progresses and is one of the biggest obstacles in developing an …
Potent induction of envelope-specific antibody responses by virus-like particle immunogens based on HIV-1 envelopes from patients with early broadly neutralizing …
C Beltran-Pavez, I Bontjer, N Gonzalez… - Journal of …, 2022 - Am Soc Microbiol
Longitudinal studies in HIV-1-infected individuals have indicated that 2 to 3 years of infection
are required to develop broadly neutralizing antibodies. However, we have previously …
are required to develop broadly neutralizing antibodies. However, we have previously …
High-throughput B cell epitope determination by next-generation sequencing
LM Walker, AR Shiakolas, R Venkat, ZA Liu… - Frontiers in …, 2022 - frontiersin.org
Development of novel technologies for the discovery of human monoclonal antibodies has
proven invaluable in the fight against infectious diseases. Among the diverse antibody …
proven invaluable in the fight against infectious diseases. Among the diverse antibody …
Vertical HIV-1 transmission in the setting of maternal broad and potent antibody responses
Despite the worldwide availability of antiretroviral therapy (ART), approximately 150,000
pediatric HIV infections continue to occur annually. ART can dramatically reduce HIV mother …
pediatric HIV infections continue to occur annually. ART can dramatically reduce HIV mother …
Double and Triple Combinations of Broadly Neutralizing Antibodies Provide Efficient Neutralization of All HIV-1 Strains from the Global Panel
EA Kochina, FA Urusov, AA Kruglov, DV Glazkova… - Viruses, 2022 - mdpi.com
The use of broadly neutralizing antibodies (bNAbs) is a promising approach to HIV-1
treatment. In this work, we evaluate the neutralizing activity of the following HIV-1 bNAbs …
treatment. In this work, we evaluate the neutralizing activity of the following HIV-1 bNAbs …
Detection of Neutralization-sensitive Epitopes in Antigens Displayed on Virus-Like Particle (VLP)-Based Vaccines Using a Capture Assay
JF Rosengarten, S Schatz, J Stitz - JoVE (Journal of Visualized …, 2022 - jove.com
The virus-like particle (VLP) capture assay is an immunoprecipitation method, commonly
known as a'pull-down assay'used to purify and isolate antigen-displaying VLPs. Surface …
known as a'pull-down assay'used to purify and isolate antigen-displaying VLPs. Surface …
Commonly elicited antibodies against the base of the HIV-1 Env trimer guide the population-level evolution of a structure-regulating region in gp41
RA Rojas Chávez, D Boyt, N Schwery, C Han… - Journal of …, 2022 - Am Soc Microbiol
The antibody response against the HIV-1 envelope glycoproteins (Envs) guides evolution of
this protein within each host. Whether antibodies with similar target specificities are elicited …
this protein within each host. Whether antibodies with similar target specificities are elicited …
Distinct antibody profiles in HLA-B∗ 57+, HLA-B∗ 57− HIV controllers and chronic progressors
J Klingler, N Paul, G Laumond, S Schmidt, LM Mayr… - AIDS, 2022 - journals.lww.com
Objective: Spontaneous control of HIV replication without treatment in HIV-1 controllers
(HICs) was associated with the development of an efficient T-cell response. In addition …
(HICs) was associated with the development of an efficient T-cell response. In addition …
Host Factors Are Principally Responsible for Natural Resistance to Simian Immunodeficiency Virus Infection in Baboons
AR Mannino - 2022 - search.proquest.com
Human immunodeficiency virus (HIV) originated when certain strains of naturally occurring
simian immunodeficiency virus (SIV) crossed species from nonhuman primates (NHP) to …
simian immunodeficiency virus (SIV) crossed species from nonhuman primates (NHP) to …