[HTML][HTML] Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics
Y Duan, K Gong, S Xu, F Zhang, X Meng… - Signal Transduction and …, 2022 - nature.com
Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …
2021 ACC/AHA/SCAI guideline for coronary artery revascularization: a report of the American College of Cardiology/American Heart Association Joint Committee on …
Writing Committee Members, JS Lawton… - Journal of the American …, 2022 - jacc.org
Aim The guideline for coronary artery revascularization replaces the 2011 coronary artery
bypass graft surgery and the 2011 and 2015 percutaneous coronary intervention guidelines …
bypass graft surgery and the 2011 and 2015 percutaneous coronary intervention guidelines …
Long-term evolocumab in patients with established atherosclerotic cardiovascular disease
ML O'Donoghue, RP Giugliano, SD Wiviott, D Atar… - Circulation, 2022 - Am Heart Assoc
Background: In FOURIER (Further Cardiovascular Outcomes Research With PCSK9
Inhibition in Subjects With Elevated Risk), the proprotein convertase subtilisin-kexin type 9 …
Inhibition in Subjects With Elevated Risk), the proprotein convertase subtilisin-kexin type 9 …
[HTML][HTML] Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials
Background Statin therapy is effective for the prevention of atherosclerotic cardiovascular
disease and is widely prescribed, but there are persisting concerns that statin therapy might …
disease and is widely prescribed, but there are persisting concerns that statin therapy might …
[HTML][HTML] Профилактика хронических неинфекционных заболеваний в Российской Федерации. Национальное руководство 2022
ОМ Драпкина, АВ Концевая, АМ Калинина… - Кардиоваскулярная …, 2022 - cyberleninka.ru
Члены Комитета экспертов подтвердили отсутствие финансовой поддержки/конфликта
интересов. В случае сообщения о наличии конфликта интересов, член (ы) Комитета …
интересов. В случае сообщения о наличии конфликта интересов, член (ы) Комитета …
[HTML][HTML] Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation
TG Richardson, GM Leyden, Q Wang, JA Bell… - PLoS …, 2022 - journals.plos.org
Large-scale molecular profiling and genotyping provide a unique opportunity to
systematically compare the genetically predicted effects of therapeutic targets on the human …
systematically compare the genetically predicted effects of therapeutic targets on the human …
Side effects of statins: from pathophysiology and epidemiology to diagnostic and therapeutic implications
Abstract Treatment with statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A
reductase, has proven beneficial preventive effects on cardiovascular events. However …
reductase, has proven beneficial preventive effects on cardiovascular events. However …
Evaluating the association between low-density lipoprotein cholesterol reduction and relative and absolute effects of statin treatment: a systematic review and meta …
P Byrne, M Demasi, M Jones, SM Smith… - JAMA internal …, 2022 - jamanetwork.com
Importance The association between statin-induced reduction in low-density lipoprotein
cholesterol (LDL-C) levels and the absolute risk reduction of individual, rather than …
cholesterol (LDL-C) levels and the absolute risk reduction of individual, rather than …
The dawn of a new era of targeted lipid-lowering therapies
L Tokgözoğlu, P Libby - European heart journal, 2022 - academic.oup.com
Lipid risk factors for cardiovascular disease depend in part on lifestyle, but optimum control
of lipids often demands additional measures. Low-density lipoprotein (LDL) doubtless …
of lipids often demands additional measures. Low-density lipoprotein (LDL) doubtless …
High-intensity statin use among patients with atherosclerosis in the US
Background Preventive therapy among patients with established atherosclerotic
cardiovascular disease (ASCVD) is generally underused. Whether new guideline …
cardiovascular disease (ASCVD) is generally underused. Whether new guideline …