Lung cancer stem cell markers as therapeutic targets: an update on signaling pathways and therapies

Y Zheng, L Wang, L Yin, Z Yao, R Tong, J Xue… - Frontiers in …, 2022 - frontiersin.org
Cancer stem cells, a relatively small group of self-renewing cancer cells, were first isolated
from acute myeloid leukemia. These cells can play a crucial role in tumor metastasis …

How mechanisms of stem cell polarity shape the human cerebral cortex

MG Andrews, L Subramanian, J Salma… - Nature Reviews …, 2022 - nature.com
Apical–basal progenitor cell polarity establishes key features of the radial and laminar
architecture of the developing human cortex. The unique diversity of cortical stem cell …

Role of CD133/NRF2 axis in the development of colon cancer stem cell-like properties

J Park, SK Kim, SP Hallis, BH Choi, MK Kwak - Frontiers in Oncology, 2022 - frontiersin.org
Cancer stem cells (CSCs) exhibit intrinsic therapy/stress resistance, which often cause
cancer recurrence after therapy. In this study, we investigated the potential relationship …

Prominin 1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epithelium

CFH Serra, H Liu, J Qian, M Mori, J Lu, WV Cardoso - IScience, 2022 - cell.com
Differences in ciliary morphology and dynamics among multiciliated cells of the respiratory
tract contribute to efficient mucociliary clearance. Nevertheless, little is known about how …

Asymmetric pericentrosomal CD133 endosomes induce the unequal autophagic activity during cytokinesis in CD133-positive human neuroblastoma cells

H Izumi, Y Li, M Yasunami, S Sato, T Mae… - Stem Cells, 2022 - academic.oup.com
CD133 is a transmembrane protein that mainly localizes to the plasma membrane in
hematopoietic/neural stem cells and cancer stem cells. Although CD133 also localizes to the …

A lateral protrusion latticework connects neuroepithelial cells and is regulated during neurogenesis

I Kasioulis, A Dady, J James, A Prescott… - Journal of Cell …, 2022 - journals.biologists.com
Dynamic contacts between cells within the developing neuroepithelium are poorly
understood but play important roles in cell and tissue morphology and cell signalling. Here …

Host cell membrane proteins located near SARS-CoV-2 spike protein attachment sites are identified using proximity labeling and proteomic analysis

N Kotani, T Nakano, R Kuwahara - Journal of Biological Chemistry, 2022 - ASBMB
Coronavirus disease represents a real threat to the global population, and understanding
the biological features of the causative virus, that is, severe acute respiratory syndrome …

FASN-dependent de novo lipogenesis is required for brain development

D Gonzalez-Bohorquez… - Proceedings of the …, 2022 - National Acad Sciences
Fate and behavior of neural progenitor cells are tightly regulated during mammalian brain
development. Metabolic pathways, such as glycolysis and oxidative phosphorylation, that …

[HTML][HTML] The prominin-like gene expressed in a subset of dopaminergic neurons regulates locomotion in Drosophila

TH Ryu, M Subramanian, E Yeom, K Yu - Molecules and cells, 2022 - Elsevier
CD133, also known as prominin-1, was first identified as a biomarker of mammalian cancer
and neural stem cells. Previous studies have shown that the prominin-like (promL) gene, an …

A novel stem cell type at the basal side of the subventricular zone maintains adult neurogenesis

K Baur, Y Abdullah, C Mandl, G Hölzl‐Wenig, Y Shi… - EMBO …, 2022 - embopress.org
According to the current consensus, murine neural stem cells (NSCs) apically contacting the
lateral ventricle generate differentiated progenitors by rare asymmetric divisions or by …