Acute lymphoblastic leukemia (ALL) is a heterogeneous group of hematologic malignancies
characterized by abnormal proliferation of immature lymphoid cells. It is the most commonly …

The release of cytokines from epithelial and stromal cells is critical for the initiation and
maintenance of tissue immunity. Three such cytokines, thymic stromal lymphopoietin, IL-33 …

Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, arising from
immature lymphocytes that show uncontrolled proliferation and arrested differentiation …

Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a high-risk
subtype of B-ALL often associated with genetic variants that alter cytokine receptor …

Aberrant activation of the JAK-STAT signaling pathway has been implicated in the
pathogenesis of a range of hematological malignancies and autoimmune disorders. Here …

The genetic basis of the predisposition for Down Syndrome (DS) patients to develop
cytokine receptor-like factor 2 rearranged (CRLF2r) acute lymphoblastic leukemia (ALL) is …

Characterizing the genomic landscape of cancers is a routine part of clinical care that began
with the discovery of the Philadelphia chromosome and has since coevolved with genomic …

Abstract Cytokine Receptor-Like Factor 2 (CRLF2) overexpression occurs in 5-15% of B-cell
precursor acute lymphoblastic leukaemia (B-ALL). In∼ 50% of these cases, the mechanisms …

Background: BCR/ABL1-like acute lymphoblastic leukemia is a newly recognized high-risk
subtype of ALL, characterized by the presence of genetic alterations activating kinase and …

Children with Down syndrome (DS) have a greater than 100-fold increased risk of
developing acute myeloid leukemia (ML) and an approximately 30-fold increased risk of …