[HTML][HTML] Inflammation and infection in cystic fibrosis: update for the clinician

A Petrocheilou, A Moudaki, AG Kaditis - Children, 2022 - mdpi.com
Inflammation and infection play an important role in the pathophysiology of cystic fibrosis,
and they are significant causes of morbidity and mortality in CF. The presence of thick mucus …

[PDF][PDF] Novel applications of biomarkers and personalized medicine in cystic fibrosis

JS Guimbellot, DP Nichols, JJ Brewington - Clinics in Chest Medicine, 2022 - Elsevier
The rapid pace of recent advancements in CF has led to significant improvements in patient
outcomes and has created new opportunities to personalize care decisions. Numerous …

Development of excipients free inhalable co-spray-dried tobramycin and diclofenac formulations for cystic fibrosis using two and three fluid nozzles

N Marasini, Z Sheikh, CYJ Wong, M Hosseini… - International Journal of …, 2022 - Elsevier
This study aims to investigate the effect of physicochemical properties and aerosol
performance of two (2FN) and three-fluid nozzles (3FN) on the inhalable co-formulation of …

Pseudomonas aeruginosa modulates neutrophil granule exocytosis in an in vitro model of airway infection

DR Laucirica, CJ Schofield, SA McLean… - … and Cell Biology, 2022 - Wiley Online Library
A population of neutrophils recruited into cystic fibrosis (CF) airways is associated with
proteolytic lung damage, exhibiting high expression of primary granule exocytosis marker …

[HTML][HTML] Novel immunomodulatory therapies for respiratory pathologies

LP Tavares, I Galvão, MR Ferrero - Comprehensive Pharmacology, 2022 - ncbi.nlm.nih.gov
The respiratory tract is constantly exposed to environmental aggressions including
allergens, infections, and pollution. The immune system is pivotal to fight potential invaders …

The potential benefit of rooibos (Aspalathus linearis) in pulmonary arterial hypertension: A short review

GJ Maarman, S Lecour - South African Journal of Botany, 2022 - Elsevier
Rooibos is a uniquely South African plant cultivated to produce rooibos herbal tea or extract
and often incorporated into iced herbal tea, soap, skin lotion, facewash, and shampoo …

[HTML][HTML] Современные подходы к ведению детей с муковисцидозом

АА Баранов, ЛС Намазова-Баранова… - Педиатрическая …, 2022 - cyberleninka.ru
Проблема своевременной диагностики и правильного ведения пациентов с
муковисцидозом актуальна не только в нашей стране, но и во всем мире. Экспертами …

Current evidence on the effect of highly effective CFTR modulation on interleukin-8 in cystic fibrosis

M Williamson, M Casey, C Gabillard-Lefort… - Expert Review of …, 2022 - Taylor & Francis
Introduction Cystic fibrosis (CF) is a genetically inherited disease, with mortality and
morbidity associated with respiratory disease. The inflammatory response in CF is …

Pharmacogenomics: a tool to improve medication safety and efficacy in patients with cystic fibrosis

CM Sakon, EM Tillman - Pharmacogenomics, 2022 - Taylor & Francis
Cystic fibrosis is a genetic, multiorgan system disease that involves the use of many
medications to control symptoms associated with the underlying condition. Many of these …

Roscovitine Worsens Mycobacterium abscessus Infection by Reducing DUOX2-mediated Neutrophil Response

V Le Moigne, D Rodriguez Rincon… - American Journal of …, 2022 - atsjournals.org
Persistent neutrophilic inflammation associated with chronic pulmonary infection causes
progressive lung injury and, eventually, death in individuals with cystic fibrosis (CF), a …