NAD+, Sirtuins and PARPs: Enhancing oocyte developmental competence

CL Pollard, Z Gibb, A Swegen… - Journal of Reproduction …, 2022 - jstage.jst.go.jp
Oocyte quality is the limiting factor in female fertility. It is well known that maternal nutrition
plays a role in reproductive function, and manipulating nutrition to improve fertility in …

Metabolic and nonmetabolic functions of PSAT1 coordinate signaling cascades to confer EGFR inhibitor resistance and drive progression in lung adenocarcinoma

MY Luo, Y Zhou, WM Gu, C Wang, NX Shen, JK Dong… - Cancer Research, 2022 - AACR
Emerging evidence demonstrates that the dysregulated metabolic enzymes can accelerate
tumorigenesis and progression via both metabolic and nonmetabolic functions. Further …

Identification of partial denitrification granulation enhanced by low C/N ratio in the aspect of metabolomics and quorum sensing

C Ma, W Zeng, Q Meng, C Wang, Y Peng - Chemosphere, 2022 - Elsevier
Partial denitrification granular sludge (PDGS) and denitrification granular sludge (DGS) play
an important role in nitrogen removal from wastewater. However, the inherent cause of …

Tryptophan metabolism 'Hub'gene expression associates with increased inflammation and severe disease outcomes in COVID-19 infection and inflammatory bowel …

S Bustamante, Y Yau, V Boys, J Chang… - International Journal of …, 2022 - mdpi.com
The epithelial barrier's primary role is to protect against entry of foreign and pathogenic
elements. Both COVID-19 and Inflammatory Bowel Disease (IBD) show commonalities in …

Lower citrate synthase activity, mitochondrial complex expression, and fewer oxidative myofibers characterize skeletal muscle from growth-restricted fetal sheep

J Stremming, EI Chang, LA Knaub… - American Journal …, 2022 - journals.physiology.org
Skeletal muscle from the late gestation sheep fetus with intrauterine growth restriction
(IUGR) has evidence of reduced oxidative metabolism. Using a sheep model of placental …

Spatiotemporal monitoring of NAD+ metabolism with fluorescent biosensors

W Chen, S Liu, Y Yang, Z Zhang, Y Zhao - Mechanisms of Ageing and …, 2022 - Elsevier
Nicotinamide adenine dinucleotide (NAD+) plays vital roles in cell metabolism, cell
signaling, and gene expression regulation. NAD+ shows intricate subcellular distribution …

Improvement of tissue‐specific distribution and biotransformation potential of nicotinamide mononucleotide in combination with ginsenosides or resveratrol

LB Bai, LF Yau, TT Tong, WH Chan… - Pharmacology …, 2022 - Wiley Online Library
Decreased Nicotinamide adenine dinucleotide (NAD+) level has received increasing
attention in recent years since it plays a critical role in many diseases and aging. Although …

[HTML][HTML] Declining muscle NAD+ in a hyperandrogenism PCOS mouse model: possible role in metabolic dysregulation

A Aflatounian, VR Paris, D Richani, MC Edwards… - Molecular …, 2022 - Elsevier
Polycystic ovary syndrome (PCOS) is a common endocrine disorder, defined by
reproductive and endocrine abnormalities, with metabolic dysregulation including obesity …

Supplemental Nicotinic Acid Elevates NAD+ Precursors in the Follicular Fluid of Mares

CL Pollard, Z Gibb, J Clulow, A Ruiz, A Sheridan… - Animals, 2022 - mdpi.com
Simple Summary Miscarriage and embryonic death have been associated with a deficiency
in NAD+ resulting from a lack of dietary niacin in women and mice. Mares often suffer from …

Brain Cell Viability and the Cellular Adaptive Response

F Khorshidi - 2022 - unsworks.unsw.edu.au
Hormesis or the adaptive stress response is a biphasic dose response to a factor which has
a beneficial effect on cells or an organism at low doses while having a toxic effect at higher …