The anti-inflammatory and immunological properties of GLP-1 Receptor Agonists

G Bendotti, L Montefusco, ME Lunati, V Usuelli… - Pharmacological …, 2022 - Elsevier
In the last few years, a great interest has emerged in investigating the pleiotropic effects of
Glucagon Like Peptide-1 Receptor Agonists (GLP-1RAs). While GLP-1RAs ability to lower …

Immune and non-immune functions of adipose tissue leukocytes

WV Trim, L Lynch - Nature Reviews Immunology, 2022 - nature.com
Adipose tissue is a complex dynamic organ with whole-body immunometabolic influence.
Much of the work into understanding the role of immune cells in adipose tissue has been in …

Adipose tissue macrophage in obesity-associated metabolic diseases

J Yao, D Wu, Y Qiu - Frontiers in immunology, 2022 - frontiersin.org
Adipose tissue macrophage (ATM) has been appreciated for its critical contribution to
obesity-associated metabolic diseases in recent years. Here, we discuss the regulation of …

Resident and migratory adipose immune cells control systemic metabolism and thermogenesis

K Man, A Kallies, A Vasanthakumar - Cellular & molecular immunology, 2022 - nature.com
Glucose is a vital source of energy for all mammals. The balance between glucose uptake,
metabolism and storage determines the energy status of an individual, and perturbations in …

Obesity-mediated immune modulation: one step forward,(Th) 2 steps back

V Schmidt, AE Hogan, PG Fallon… - Frontiers in …, 2022 - frontiersin.org
Over the past decades, the relationship between the immune system and metabolism has
become a major research focus. In this arena of immunometabolism the capacity of adipose …

Importance of the microenvironment and mechanosensing in adipose tissue biology

S Lecoutre, M Lambert, K Drygalski, I Dugail… - Cells, 2022 - mdpi.com
The expansion of adipose tissue is an adaptive mechanism that increases nutrient buffering
capacity in response to an overall positive energy balance. Over the course of expansion …

Effect of metformin and exenatide on pregnancy rate and pregnancy outcomes in overweight or obese infertility PCOS women: long-term follow-up of an RCT

R Li, T Mai, S Zheng, Y Zhang - Archives of Gynecology and Obstetrics, 2022 - Springer
Abstract Purpose The majority of Polycystic ovary syndrome (PCOS) are overweight or
obese with increased infertility and high risk of pregnancy complications. We aim to compare …

Role of innate lymphoid cells in obesity and insulin resistance

H Chen, L Sun, L Feng, Y Yin, W Zhang - Frontiers in Endocrinology, 2022 - frontiersin.org
Obesity, a growing chronic metabolic disease, greatly increases the risk of metabolic
syndrome which includes type 2 diabetes, fatty liver and cardiovascular diseases. Obesity …

Liraglutide activates type 2 deiodinase and enhances β3-adrenergic-induced thermogenesis in mouse adipose tissue

FCB Oliveira, EJ Bauer, CM Ribeiro… - Frontiers in …, 2022 - frontiersin.org
Aims Liraglutide is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist used as
an anti-hyperglycemic agent in type 2 diabetes treatment and recently approved for obesity …

Immune cell cholinergic signaling in adipose thermoregulation and immunometabolism

Y Ma, H Jun, J Wu - Trends in immunology, 2022 - cell.com
Research focusing on adipose immunometabolism has been expanded from inflammation
in white fat during obesity development to immune cell function regulating thermogenic fat …