Mitochondrial metabolism mediated macrophage polarization in chronic lung diseases

T Dong, X Chen, H Xu, Y Song, H Wang, Y Gao… - Pharmacology & …, 2022 - Elsevier
As the first line of defence in the lung, alveolar macrophage contributes to maintaining lung
immune homoeostasis. Characterized by the heterogeneity and plasticity, macrophages …

Recent evidence from omic analysis for redox signalling and mitochondrial oxidative stress in COPD

S Mumby, IM Adcock - Journal of inflammation, 2022 - Springer
COPD is driven by exogenous and endogenous oxidative stress derived from inhaled
cigarette smoke, air pollution and reactive oxygen species from dysregulated mitochondria …

Oxidative stress in chronic obstructive pulmonary disease

PJ Barnes - Antioxidants, 2022 - mdpi.com
There is a marked increase in oxidative stress in the lungs of patients with COPD, as
measured by increased exhaled 8-isoprostane, ethane, and hydrogen peroxide in the …

Autocrine, Paracrine, and Endocrine Signals That Can Alter Alveolar Macrophages Function

Y Yang, Y Wang - Reviews of Physiology, Biochemistry and …, 2022 - Springer
Alveolar macrophages (AMs) are extremely versatile cells with complex functions involved in
health or diseases such as pneumonia, asthma, and pulmonary alveolar proteinosis. In …