The PPARγ agonist pioglitazone produces a female-predominant inhibition of hyperalgesia associated with surgical incision, peripheral nerve injury, and painful …
Pioglitazone, an agonist at peroxisome proliferator-activated receptor gamma, is FDA-
approved for the treatment of insulin resistance in type 2 diabetes. Numerous studies in …
approved for the treatment of insulin resistance in type 2 diabetes. Numerous studies in …
Soluble epoxide hydrolase and diabetes complications
NZ Anita, W Swardfager - International Journal of Molecular Sciences, 2022 - mdpi.com
Type 2 diabetes mellitus (T2DM) can result in microvascular complications such as
neuropathy, retinopathy, nephropathy, and cerebral small vessel disease, and contribute to …
neuropathy, retinopathy, nephropathy, and cerebral small vessel disease, and contribute to …
Cellular distribution of cannabinoid‐related receptors TRPV1, PPAR‐gamma, GPR55 and GPR3 in the equine cervical dorsal root ganglia
G Galiazzo, M De Silva, F Giancola… - Equine Veterinary …, 2022 - Wiley Online Library
Background The activation of cannabinoid and cannabinoid‐related receptors by
endogenous, plant‐derived or synthetic cannabinoids may exert beneficial effects on pain …
endogenous, plant‐derived or synthetic cannabinoids may exert beneficial effects on pain …
Peroxisome proliferator-activated receptor gamma agonist ELB00824 suppresses oxaliplatin-induced pain, neuronal hypersensitivity, and oxidative stress
M Zhang, M Hu, SRA Alles, MA Montera, I Adams… - …, 2022 - Elsevier
Chemotherapy-induced neuropathic pain (CINP) is a debilitating and difficult-to-treat side
effect of chemotherapeutic drugs. CINP is marked with oxidative stress and neuronal …
effect of chemotherapeutic drugs. CINP is marked with oxidative stress and neuronal …
Cisplatin-induced changes in calcitonin gene-related peptide or TNF-α release in rat dorsal root ganglia in vitro model of neurotoxicity are not reverted by rosiglitazone
HR Oliveira, MS Coelho, FAR Neves, DB Duarte - Neurotoxicology, 2022 - Elsevier
Introduction Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect
of anticancer drugs which affect the peripheral nervous system, as occurs with cisplatin …
of anticancer drugs which affect the peripheral nervous system, as occurs with cisplatin …
Recent developments and challenges in positron emission tomography imaging of gliosis in chronic neuropathic pain
Understanding the mechanisms that underpin the transition from acute to chronic pain is
critical for the development of more effective and targeted treatments. There is growing …
critical for the development of more effective and targeted treatments. There is growing …
Compositions and methods for prophylaxis and treatment of addictions
R Ciccocioppo - US Patent 11,241,420, 2022 - Google Patents
The present invention relates to methods of treating or preventing addiction and relapse use
of addictive agents, and treating or preventing addictive or compulsive behaviour and …
of addictive agents, and treating or preventing addictive or compulsive behaviour and …