Uric acid (UA) is the final product of purine metabolism in the human body, and impaired
purine metabolism can increase the uric acid in serum, finally resulting in hyperuricemia …

Gouty arthritis (GA), as a multifactorial disease, is characterised by intense pain, active
inflammation symptoms, and swollen joints. It has utterly complex pathogenesis, of which the …

Objective To develop recommendations for cardiovascular risk (CVR) management in gout,
vasculitis, systemic sclerosis (SSc), myositis, mixed connective tissue disease (MCTD) …

La enfermedad renal crónica (ERC) es un importante problema de salud pública a nivel
mundial afectando a más del 10% de la población española. Se asocia a elevada …

Background The relative efficacy and safety of allopurinol and febuxostat when used
according to current guidelines for the treatment of hyperuricemia are unknown. This double …

Biologic drugs have transformed the standard of care for many diseases. However, many
biologics induce the formation of anti-drug antibodies (ADAs), which can compromise their …

Alcohol is recognized a risk factor for increased uric acid and gout flare. The aim of the study
was to review the literature in order to find out what is the role of alcohol consumption in …

Objective The predominant mechanism driving hyperuricemia in gout is renal uric acid
underexcretion; however, the standard urate‐lowering therapy (ULT) recommendation is first …

Background Asymptomatic hyperuricemia was found to be associated with increased
cardiovascular disease risk but the potential benefits of urate-lowering therapy (ULT) remain …

Background The incidence and prevalence of gout have been steadily increasing globally,
which has resulted in gout research attracting consistently increased attention. This study …